A certain number of polyps of the vocal folds result from violent, intense and unaccustomed physical activity. The development of these polyps is certainly linked to high subglottal pressure and the abrupt reduction of the same.
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Comput Struct Biotechnol J
December 2024
National Vaccine Innovation Platform, Scholl of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Unlabelled: The prevention and treatment of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), have emerged as critical global health challenges. Current lipid-lowering pharmacotherapies are associated with side effects, including hepatotoxicity, rhabdomyolysis, and decreased erythrocyte counts, underscoring the urgent need for safer therapeutic alternatives. Hepatocyte nuclear factor 4α (HNF4α) has been identified as a pivotal regulator of lipid metabolism, making it an attractive target for drug development.
View Article and Find Full Text PDFMater Today Bio
February 2025
College of Basic Medical Sciences, The Medical Basic Research Innovation Center of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.
The use of combination therapies that employ a variety of cell death mechanisms has emerged as a promising avenue of research in the treatment of cancer. However, the optimization of therapeutic synergies when integrating different modes remains a significant challenge. To this end, we developed a multifunctional intelligent drug-carrying nanoparticle (DFMTCH NPs) based on the metal-organic framework MIL-100, loaded with doxorubicin (DOX) and disulfiram (DSF), coated with a Cu-tannic acid (Cu-TA) network and hyaluronic acid (HA), for the purpose of combined chemotherapy/chemodynamic/photothermal anti-cancer therapy.
View Article and Find Full Text PDFFood Res Int
February 2025
College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:
The advancement in heat treatment technology has spurred the innovation of various smart cooking appliances, including the steam roaster. Consequently, the technique of synchronized steaming and baking has emerged as a novel form of thermal processing. Therefore, the effects of baking, steaming, steaming-baking heating modes on the flavor of Hu sheep mutton were evaluated.
View Article and Find Full Text PDFISA Trans
December 2024
GEELY Automobile Research Institute Co. Ltd, Ningbo, Zhejiang 315699, China. Electronic address:
The voltage is one of limited reliable information for battery management system, and the faults of voltage sampling will result in adverse effects and lead to potential risks for operation, which emphasize the importance for investigating the failure modes of voltage sampling and diagnosis algorithm. In this article, a knowledge-data driven sampling diagnosis algorithm is established and an online intelligent diagnosis algorithm is proposed accordingly based on outlier detection with fuzzy entropy. The fault diagnosis algorithm is established and evaluated under positive exploitation, where the knowledge-base of failure mode based on equivalent simulating models is firstly constructed.
View Article and Find Full Text PDFUltrasonics
January 2025
State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, China.
Steel precision matching parts are widely used in aerospace and automobiles. In order to ensure the stability of the system, the matching parts' mating surfaces, such as inner holes and outer shafts, are required to achieve nano-surface roughness and submicron-shape accuracy. Diamond-cutting technology is generally used for ultra-precision machining processes.
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