The authors used in 1987-1988 Grüntzing's balloon catheter for the treatment of oesophageal strictures in nine children. They were successful in eight, in one patient after burning of the oesophagus with sulphuric acid the dilatation by means of the balloon failed. These injuries must be treated by surgery. The method is safe, easy and effective, in particular in the treatment of tight, long and irregular oesophageal strictures which cannot be dilated by the standard technique, using dilatation bougies. Dilatation by means of balloon catheters is a perspective method for severe oesophageal strictures.
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Clin Transl Gastroenterol
January 2025
Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA.
Introduction: We assessed potential mechanisms behind the requirement for more frequent dupilumab dosing in eosinophilic esophagitis (EoE) compared with other approved indications.
Methods: Results for the phase 3 LIBERTY EoE TREET study coprimary endpoints (proportion of patients achieving a peak intraepithelial eosinophil count of ≤6 eosinophils per high-power field and absolute change from baseline in Dysphagia Symptom Questionnaire total score) were pooled in exposure-response analyses.
Results: A steep initial relationship then plateau was observed between higher dupilumab steady-state trough concentrations and decreased eosinophilic infiltration at week 24, whereas a graded exposure-response relationship was observed for symptomatic improvement at week 24.
Postgrad Med J
January 2025
Department of Gastroenterology, the Second Affiliated Hospital, Army Medical University, 83th of Xin qiao Main Street, 400037 Chongqing, China.
Purpose: Endoscopic submucosal dissection (ESD) is currently one of the most curative treatments for early esophageal cancer. We conducted a retrospective case analysis to identify the characteristics of early esophageal cancer that indicate esophageal stenosis prevention measures. Our aim was to provide a reference for clinical decision-making.
View Article and Find Full Text PDFGut
January 2025
Division of Gastroenterology and Hepatology, NHC Key Laboratory of Digestive Diseases, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Rev Esp Enferm Dig
January 2025
General and Digestive Surgery. Esophagogastric Unit, Hospital Clínico Universitario Virgen de la Arrixaca.
Esophageal lichen planus (ELP) is a rare chronic inflammatory condition with delayed diagnosis that can present with dysphagia. It has been scarcely studied in the literature, and clinical management guidelines are lacking. Stenosis and neoplastic transformation are among its most feared complications.
View Article and Find Full Text PDFRev Gastroenterol Peru
January 2025
Universidad Peruana Cayetano Heredia, Lima, Perú.
We report the case of an elderly patient with progressive dysphagia to solids and later to liquids, and weight loss. The patient underwent an upper endoscopy, which showed multiple stenoses and trachealization. Biopsies were taken and a diagnosis of lymphocytic esophagitis was made.
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