The clinical picture of 6 women suffering from selective IgA immunodeficiency were studied in a 2-13 years lasting period of immunological outdoor patients care. Despite of respiratory infections, otitis media, sinusitis, aphtosis and exogenous allergy the first detection of IgA deficiency was delayed til adulthood (mean age 42 years). A case of a 22 years old women with complicated fistula after molar tooth extraction showed the problems of dentistry in such diagnosis. No significant deviation concerning periodontitis and caries has been demonstrated in all patients. However, the rate of IgA deficiency demands basic knowledge about diagnosis, prevention of local and systemic complications in this disease by all practising dentists.

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