AI Article Synopsis
- Obesity and type 2 diabetes are complex diseases influenced by both genetics and the environment.
- Recent genome-wide association studies have identified over 250 genetic locations linked to these conditions, enhancing our understanding of their underlying biology.
- The review explores the connections between obesity-related genetic factors and T2D, suggesting mechanisms that may increase susceptibility to diabetes.
Article Abstract
Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568008 | PMC |
| http://dx.doi.org/10.1007/s11892-015-0648-8 | DOI Listing |
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