AI Article Synopsis
- Extracellular matrices are important in tissue engineering for creating scaffolds due to their bioactive components.
- Noninvasive scaffold fabrication techniques help preserve these components while ensuring the scaffolds have the right structure and strength.
- Research shows that scaffolds made from bovine articular cartilage can promote the growth and differentiation of human dermal fibroblasts into cartilage-like cells, evidenced by increased production of specific molecules and gene activity.
Article Abstract
Extracellular matrices have drawn attention in tissue engineering as potential biomaterials for scaffold fabrication because of their bioactive components. Noninvasive techniques of scaffold fabrication and cross-linking treatments are believed to maintain the integrity of bioactive molecules while providing proper architectural and mechanical properties. Cartilage matrix derived scaffolds are designed to support the maintenance of chondrocytes and provide proper signals for differentiation of chondroinducible cells. Chondroinductive potential of bovine articular cartilage matrix derived porous scaffolds on human dermal fibroblasts and the effect of scaffold shrinkage on chondrogenesis were investigated. An increase in sulfated glycosaminoglycans production along with upregulation of chondrogenic genes confirmed that physically treated cartilage matrix derived scaffolds have chondrogenic potential on human dermal fibroblasts.
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| http://dx.doi.org/10.1002/jbm.a.35561 | DOI Listing |
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