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Weakly supervised chest X-ray abnormality localization with non-linear modulation and foreground control.
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School of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Chest X-ray is widely used to diagnose lung diseases. Due to the demand for accelerating analysis and interpretation to reduce the workload of radiologists, there has been a growing interest in building automated systems of chest X-ray abnormality localization. However, fully supervised methods usually require well-trained radiologists to annotate bounding boxes manually, which is labor-intensive and time-consuming.
View Article and Find Full Text PDFComparative single-cell transcriptomic analysis reveals putative differentiation drivers and potential origin of vertebrate retina.
NAR Genom Bioinform
September 2024
Department of Computational Biology and Medical Sciences, The University of Tokyo, Kashiwa 277-8563, Japan.
Despite known single-cell expression profiles in vertebrate retinas, understanding of their developmental and evolutionary expression patterns among homologous cell classes remains limited. We examined and compared approximately 240 000 retinal cells from four species and found significant similarities among homologous cell classes, indicating inherent regulatory patterns. To understand these shared patterns, we constructed gene regulatory networks for each developmental stage for three of these species.
View Article and Find Full Text PDFDo relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of US Medicaid beneficiaries with type 2 diabetes.
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Center for Real-World Effectiveness and Safety of Therapeutics, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Objective: Prior studies demonstrate that some untoward clinical outcomes vary by outdoor temperature. This is true of some endpoints common among persons with diabetes, a population vulnerable to climate change-associated health risks. Yet, prior work has been agnostic to the antidiabetes drugs taken by such persons.
View Article and Find Full Text PDFWWC2 modulates GABA-receptor-mediated synaptic transmission, revealing class-specific mechanisms of synapse regulation by WWC family proteins.
Cell Rep
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Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Psychiatry UT Southwestern Medical Center, Dallas, TX 75390, USA; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:
The WW and C2 domain-containing protein (WWC2) is implicated in several neurological disorders. Here, we demonstrate that WWC2 interacts with inhibitory, but not excitatory, postsynaptic scaffolds, consistent with prior proteomic identification of WWC2 as a putative component of the inhibitory postsynaptic density. Using mice lacking WWC2 expression in excitatory forebrain neurons, we show that WWC2 suppresses γ-aminobutyric acid type-A receptor (GABAR) incorporation into the plasma membrane and regulates HAP1 and GRIP1, which form a complex promoting GABAR recycling to the membrane.
View Article and Find Full Text PDFHealth in the age of asset manager capitalism.
Health Promot Int
October 2024
Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
A relatively small number of for-profit asset managers-financial intermediaries that invest capital on behalf of other investors-have emerged in recent decades to become some of the most influential commercial actors in the global political economy. Despite their important role in society, asset managers have received little attention from a public health perspective. In this article, we aimed to propose a conceptual framework of potential pathways and mechanisms through which asset managers may influence health and equity.
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