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Transcriptomic response of Saccharomyces cerevisiae for its adaptation to sulphuric acid-induced stress. | LitMetric

AI Article Synopsis

  • * Recent study used transcriptome analysis and physiological tests to explore how these yeast cells adapt metabolically to survive the stress from acid treatment.
  • * Key findings show that yeast survival depends on a reprogramming of metabolic pathways involving gene expression changes related to cell wall integrity, metabolism, and energy production, which could help improve industrial processes by selecting more acid-resistant yeasts.

Article Abstract

In bioethanol production plants, yeast cells are generally recycled between fermentation batches by using a treatment with sulphuric acid at a pH ranging from 2.0 to 2.5. We have previously shown that Saccharomyces cerevisiae cells exposed to sulphuric acid treatment induce the general stress response pathway, fail to activate the protein kinase A signalling cascade and requires the mechanisms of cell wall integrity and high osmolarity glycerol pathways in order to survive in this stressful condition. In the present work, we used transcriptome-wide analysis as well as physiological assays to identify the transient metabolic responses of S. cerevisiae under sulphuric acid treatment. The results presented herein indicate that survival depends on a metabolic reprogramming of the yeast cells in order to assure the yeast cell viability by preventing cell growth under this harmful condition. It involves the differential expression of a subset of genes related to cell wall composition and integrity, oxidation-reduction processes, carbohydrate metabolism, ATP synthesis and iron uptake. These results open prospects for application of this knowledge in the improvement of industrial processes based on metabolic engineering to select yeasts resistant to acid treatment.

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Source
http://dx.doi.org/10.1007/s10482-015-0568-2DOI Listing

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