Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S2215-0366(14)70368-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Sub-Anesthetic Oro-Mucosal Dexmedetomidine on Sleep in Humans: A Randomized, Controlled Pharmacokinetics-Pharmacodynamics Study.
Anesthesiology
November 2024
Institute of Pharmacology & Toxicology, University of Zurich, Zurich, Switzerland.
Article Synopsis
- The study investigates the use of dexmedetomidine, a selective α2 noradrenergic agonist, as a potential treatment for insomnia, especially in patients dealing with heightened distress, through new oro-mucosal delivery methods.
- Two formulations (sublingual and buccal) were tested in a pilot and main study involving both good and poor sleepers, focusing on pharmacokinetic and pharmacodynamic profiles alongside a range of sleep assessments.
- Results showed that buccal dexmedetomidine was quickly absorbed and effectively reduced sleep latency and increased NREM sleep duration in poor sleepers, while not significantly affecting cortisol or heart rate levels.
Nocturnal Awakening Associated with Greater Social Disconnectedness in Older Adults: The Compensatory Role of Cognition.
Clin Gerontol
October 2024
Faculty of Psychology, Southwest University, Chongqing, China.
Article Synopsis
- - The study investigated how sleep quality relates to social disconnectedness in older adults, focusing on the impact of cognitive function.
- - Findings revealed that older adults with sleep disorders experienced higher social disconnectedness, but those with better cognitive function were less affected.
- - Results indicated that issues like waking up at night were linked to social disconnect, while cognitive function could help lessen this negative effect, suggesting interventions for caregivers.
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials.
Drugs Aging
September 2024
Eisai Inc., 200 Metro Blvd, Nutley, NJ, 07110, USA.
Background: Insomnia is more common as people age. Several common hypnotics used to treat insomnia often do not adequately alleviate sleep issues in older adults and may be associated with negative residual effects such as an increased risk of falls, cognitive impairment, automobile accidents, and lack of response to auditory stimuli. The objective of these analyses of three clinical studies was to investigate the efficacy and safety of the dual orexin-receptor antagonist lemborexant (LEM) in older adults.
View Article and Find Full Text PDFAim: The aim of this study was to investigate the association of psychological and chronobiological factors with the presence and severity of chronic insomnia by symptom subtypes and their impacts on daytime dysfunctions.
Methods: Participants of the present web-based epidemiological study were classified as follows: difficulty initiating sleep (DIS) ( = 91); difficulty maintaining sleep (DMS) ( = 13); early morning awakening (EMA) ( = 48); DIS + DMS ( = 67); DIS + EMA ( = 23); DMS + EMA ( = 24); triplet of DIS, DMS, and EMA symptoms (TRP) ( = 69); and normal sleepers ( = 4590). The Insomnia Severity Index (ISI), Hospital Anxiety and Depression Scale (HADS), Munich Chronotype Questionnaire (MCTQ), insomnia-related psychological measures (including the Ford Insomnia Response to Stress Test [FIRST] and the Dysfunctional Beliefs and Attitudes about Sleep Scale [DBAS]), and the cognitive and somatic domains of the Pre-Sleep Arousal Scale (PSAS) were evaluated.
Sleep disturbances in late pregnancy: associations with induction of labor.
Arch Gynecol Obstet
October 2024
Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Savitehtaankatu 5, 20521, Turku, Finland.
Purpose: Sleep disturbances, which are common during pregnancy, may compromise labor. Nevertheless, little is known about associations between sleep disturbances and the likelihood of ending up induction of labor (IOL). Accordingly, we aimed to evaluate the connections between sleep disturbances during pregnancy and IOL.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!