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Biolayer interferometry is insufficiently sensitive for direct measurement of IgM quantity and avidity in Atlantic salmon (Salmo salar) serum.
Fish Shellfish Immunol
March 2023
The University of Queensland, School of Biological Sciences, Brisbane, QLD, 4072, Australia.
Quantification of specific antibodies underpins the assessment of adaptive immunity in response to vaccination or infection and is performed by enzyme-linked immunosorbent assay (ELISA). A biolayer interferometry (BLI) assay was recently developed that simultaneously quantifies IgM antibodies and their avidity in giant grouper (Epinephelus lanceolatus) sera and proved to be a robust, repeatable and more high-throughput alternative to ELISA [1]. Here we attempted to optimise a similar single-step BLI assay using an Octet HTX instrument to quantify IgM specific to the hapten 2,4-dinitrophenol (DNP) in serum from Atlantic salmon (Salmo salar) primed and boosted with DNP conjugated to keyhole limpet hemocyanin.
View Article and Find Full Text PDFOn the Effect of Lattice Topology on Mechanical Properties of SLS Additively Manufactured Sheet-, Ligament-, and Strut-Based Polymeric Metamaterials.
Polymers (Basel)
October 2022
Advanced Digital & Additive Manufacturing Center, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.
Cellular lattices with architectural intricacy or metamaterials have gained a substantial amount of attention in the past decade due to the recent advances in additive manufacturing methods. The lattice topology controls its physical and mechanical properties; therefore, the main challenge is selecting the appropriate lattice topology for a desired function and application. In this work, we comprehensively study the topology-property relationship of three classes of polymer metamaterials based on triply periodic minimal surfaces (TPMS) of sheet/shell and ligament types, and other types of well-known strut-based lattices.
View Article and Find Full Text PDFHigh-strength porous biomaterials for bone replacement: A strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth and manufacturing constraints.
Acta Biomater
January 2016
Mechanical Engineering Department, McGill University, Montreal, Quebec H3A0C3, Canada. Electronic address:
Unlabelled: High-strength fully porous biomaterials built with additive manufacturing provide an exciting opportunity for load-bearing orthopedic applications. While factors controlling their mechanical and biological response have recently been the subject of intense research, the interplay between mechanical properties, bone ingrowth requirements, and manufacturing constraints, is still unclear. In this paper, we present two high-strength stretch-dominated topologies, the Tetrahedron and the Octet truss, as well as an intuitive visualization method to understand the relationship of cell topology, pore size, porosity with constraints imposed by bone ingrowth requirements and additive manufacturing.
View Article and Find Full Text PDFOCTET does not prove community treatment orders are ineffective.
Lancet Psychiatry
May 2015
Coventry and Warwickshire NHS Partnership Trust, St Michaels Hospital, St Michaels Rd, Warwick, CV34 5QW, UK.
Recognization of receptors on bone marrow-derived dendritic cells bound with Pholiota nameko polysaccharides.
Int J Biol Macromol
January 2015
Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, PR China.
Three major active polysaccharides isolated from Pholiota nameko (PNPS), including PNPS-1, PNPS-2 and PNPS-3, had been proved to inhibit the maturation of the murine bone marrow-derived dendritic cells (BMDCs). This paper recognized the affinity bind between PNPS and the five receptors (TLR2, TLR4, CD14, Dectin-1 and Mannose receptor) on BMDCs, using the bio-layer interferometry (BLI)-based biosensor technology developed by ForteBio on Octet RED system (Fortebio, Inc.).
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