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Parametric imaging of myocardial blood flow with Rb PET: An accuracy and image quality analysis.
J Nucl Cardiol
October 2024
University of Ottawa Heart Institute, Cardiac Imaging, Ottawa, ON, Canada; University of Ottawa, Electrical Engineering and Computer Science, Ottawa, ON, Canada. Electronic address:
Background: We aimed to develop a framework for generating three-dimensional (3D) myocardial blood flow (MBF) images, computing their accuracy against clinically validated two-dimensional (2D) polar MBF maps of the left ventricle, and evaluating their improvements in image quality over relative myocardial perfusion imaging (MPI).
Methods: N = 40 patients with a wide range of defect severities and uptake dynamics were retrospectively studied. The FlowQuant™ software was used to generate reference MPI and polar MBF maps and was adapted for voxel-wise MBF mapping.
The physiological basis of renal nuclear medicine.
Nucl Med Commun
September 2024
Department of Nuclear Medicine, King's College Hospital, London, UK.
Renal physiology underpins renal nuclear medicine, both academic and clinical. Clearance, an important concept in renal physiology, comprises tissue uptake rate of tracer (tissue clearance), disappearance rate from plasma (plasma clearance), appearance rate in urine (urinary clearance) and disappearance rate from tissue. In clinical research, steady-state plasma clearances of para-amino-hippurate and inulin have been widely used to measure renal blood flow (RBF) and glomerular filtration rate (GFR), respectively.
View Article and Find Full Text PDFRole of serial F-fludeoxyglucose positron emission tomography in determining the therapeutic efficacy of immunosuppression and clinical outcome in patients with cardiac sarcoidosis.
J Nucl Cardiol
May 2024
Cardiac Sarcoidosis Service, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom; Department of Nuclear Medicine and PET, Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Background: Myocardial inflammation and perfusion defects detected by F-fludeoxyglucose (FDG) and Rubidium-82 positron emission tomography (PET) may be associated with ventricular arrhythmias (VAs) in cardiac sarcoidosis (CS). The role of serial quantitative PET in determining the effect of treatment on myocardial inflammation and clinical outcomes is yet to be defined.
Methods: Newly diagnosed CS patients with active myocardial inflammation (maximum standardised uptake value (SUVmax) ≥ 2.
The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events, Evaluation of Colchicine Effectiveness (CADENCE): protocol for a randomised, double-blind, placebo-controlled trial.
BMJ Open
November 2023
University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Background: Inflammation is a key mediator in the development and progression of the atherosclerotic disease process as well as its resultant complications, like myocardial infarction (MI), stroke and cardiovascular (CV) death, and is emerging as a novel treatment target. Trials involving anti-inflammatory medications have demonstrated outcome benefit in patients with known CV disease. In this regard, colchicine appears to hold great promise.
View Article and Find Full Text PDFArticle Synopsis
- Splenic switch-off (SSO) occurs when there is reduced splenic radiotracer uptake after stress, and this study investigates how regadenoson-induced SSO could help diagnose coronary artery disease (CAD).* -
- In a study of patients undergoing PET-MPI for CAD, a significant decrease in splenic uptake was observed, with 28% identified as splenic non-responders, who also had lower myocardial flow reserves compared to responders.* -
- The findings suggest that those with a lack of splenic response are more likely to have obstructive coronary disease, indicating that SSO assessment could effectively highlight patients needing further evaluation.*
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