Aim: To identify main clinical/psychopathological characteristics of aged psychiatric inpatients who regularly used anxiolytic and hypnotic benzodiazepines without control from the physician.
Material And Methods: Authors examined 56 women over 50 years hospitalized due to a psychiatric disorder. Before admission, they regularly used benzodiazepines without a prescription for more than 2 months. The patients were studied during 4 weeks in the hospital. To assess the severity and dynamics of their condition, we administered psychopathological analysis and common psychometric scales as well as our own version of the scale for benzodiazepine dependence.
Results And Conclusion: The diagnosis of drug dependence was based on the three criteria: symptoms of pathological dependence of benzodiazepine, benzodiazepine withdrawal syndrome with severe somatic/autonomic symptoms and exacerbation of dependence, increase in tolerability to benzodiazepine anxiolytics and hypnotics; 64.3% of the patients met these criteria. An analysis of risk factors for this disease in elderly demonstrated the higher risk in patients aged ≤ 60 years and in those who used diazepam. The risk was higher in patients who preferred phenazepam.
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http://dx.doi.org/10.17116/jnevro20151157147-59 | DOI Listing |
Spec Care Dentist
January 2025
Department of Periodontology, Faculty of Dental Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
Aims: To assess and compare the effectiveness of pharmacological and cognitive-behavioral modalities-behavioral methods (BM), nitrous oxide inhalation sedation (NOIS), and premedication with Diazepam-for alleviating anxiety during dental treatment, using completed treatment sessions and adverse outcomes as indicators.
Methods And Results: For 239 patients (515 dental records), 18-53 y/o, who underwent dental treatments under anxiety reduction measures, sessions under NOIS were categorized as "nitrous group" (456 sessions) versus premedication with Diazepam or behavioral strategies (control, 59 sessions). Outcomes were completed treatment sessions considering demographic and clinical parameters, and adverse outcomes during and between sessions.
PLoS Biol
January 2025
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America.
Worrying about perceived threats is a hallmark of multiple psychological disorders including anxiety. This concern about future events is particularly important when an individual is faced with an approach-avoidance conflict. Potential goals to approach are known to be represented in the dorsal hippocampus during theta cycles.
View Article and Find Full Text PDFOral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Nara Medical University, 840, Shijo-Cho, 634-8522, Kashihara, Nara, Japan.
Purpose: This study aimed to analyze changes in anxiety and comfort levels at each perioperative stage during third molar extraction under single-agent intravenous midazolam sedation, and to clarify how these conditions at each perioperative stage affect postoperative satisfaction.
Patients And Method: 115 who requested extraction of 1 ~ 4 third molars under single-agent intravenous midazolam sedation were targeted. These patients were administered a questionnaire survey one week after surgery.
Eur J Pharmacol
January 2025
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan; Department of Pharmacy, Korea University, Sejong, 20019, South Korea. Electronic address:
The study investigated the anxiolytic, antidepressant, sedative/hypnotic and in silico molecular docking properties of the synthetic ephedrine-based derivative of thiourea, 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methylthiourea. Safety profile of the compound at various doses was determined in an acute toxicity test. Results showed significant anti-anxiety effects of the compound in all mice studies.
View Article and Find Full Text PDFJ Clin Med
December 2024
Département d'Anesthésie-Réanimation, Douleur, Hôpital de la Croix Rousse, Hospices Civils de Lyon, 69004 Lyon, France.
Chronic pain is a common symptom in Post-Acute COVID-19 Syndrome (PACS), affecting 11-60% of patients, but the link between COVID-19 and chronic pain remains unclear. This study assesses healthcare resource utilization (HRU) for pain management among French COVID-19 survivors, using the National French Claims Database (SNDS). We analyzed medical consultations, rehabilitation services, diagnostic procedures, and medication dispensing to identify PACS-related pain patterns and their impact on the healthcare system.
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