AI Article Synopsis
- A study compared the effectiveness and safety of modern antidepressants (venlafaxine, agomelatine, fluvoxamine) alone versus in combination with acetyl-L-carnitine in older adults with depression.
- Two groups of elderly patients (ages 60-79) with mild to moderate depression were treated for 8 weeks, either with just the antidepressant or along with carnicetine.
- The findings indicated that the combination therapy was more effective, showed faster improvements in symptoms like depression and anxiety, and resulted in fewer side effects, suggesting it could be a better treatment option for older patients.
Article Abstract
Aim: A comparative evaluation of the efficacy and safety of monotherapy with one of the modern antidepressants (venlafaxine, agomelatine, or fluvoxamine) and combination treatment of one of the above mentioned antidepressants with acetyl-L-carnitine (ALС, carnicetine) in the geriatric psychiatric unit.
Material And Methods: Two groups of elderly patients (aged 60-79 years) with mild or moderate depression, randomized according to a number of demographic and clinical characteristics, were treated with antidepressants in monotherapy or combined therapy (antidepressant/carnicetine) within 8 weeks.
Results: Combination therapy with the neurotrophic agent carnicetine proved to be more effective compared to monotherapy. At the end of treatment, the more rapid clinical response has been shown for depression, anxiety, apathy, and cognitive dysfunction. Furthermore, combination therapy provides less adverse effects.
Conclusion: Antidepressant/carnicetine combination therapy may be recommended for treatment of depression in elderly patients.
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| http://dx.doi.org/10.17116/jnevro20151156124-32 | DOI Listing |
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