AI Article Synopsis
- The study assessed morphometric and morphological features in paragangliomas from various sites, finding that these tumors have higher cell density and rounder nuclei compared to normal paraganglia.
- While the nuclear area in both tumors and normal paraganglia shows similar mean values, paragangliomas exhibit greater variability in nuclear size, particularly in the aorticopulmonary and aortico-sympathetic subtypes.
- Despite different morphological characteristics and clinical behaviors, no significant morphometric differences were identified when analyzing subgroups based on architectural patterns, site of origin, or recurrence/metastasis.
Article Abstract
Morphometric and morphological parameters have been evaluated in tumours of carotid body paraganglia and of aorticopulmonary and aorticosympathetic paraganglia. Paragangliomas are characterized by a higher cell density and rounder nuclei (roundness factor) than non-neoplastic carotid body paraganglia. The nuclear area has similar mean values in tumours and normal paraganglia; however, the former group shows higher standard deviation values and coefficients of variation, reflecting the fact that paragangliomas have nuclei of variable size; the variation is more pronounced in aorticopulmonary and aortico-sympathetic paragangliomas. However, subgroups on the basis of morphological features (architectural patterns and degree of intensity of argyrophilia), site of origin, and clinical behaviour (metastases and recurrences) show no morphometric differences.
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