Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920077 | PMC |
http://dx.doi.org/10.1016/j.chom.2015.08.012 | DOI Listing |
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