Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing.

Cell Host Microbe

Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA. Electronic address:

Published: September 2015

Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920077PMC
http://dx.doi.org/10.1016/j.chom.2015.08.012DOI Listing

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