Mean shift clustering is a powerful nonparametric technique that does not require prior knowledge of the number of clusters and does not constrain the shape of the clusters. However, being completely unsupervised, its performance suffers when the original distance metric fails to capture the underlying cluster structure. Despite recent advances in semi-supervised clustering methods, there has been little effort towards incorporating supervision into mean shift. We propose a semi-supervised framework for kernel mean shift clustering (SKMS) that uses only pairwise constraints to guide the clustering procedure. The points are first mapped to a high-dimensional kernel space where the constraints are imposed by a linear transformation of the mapped points. This is achieved by modifying the initial kernel matrix by minimizing a log det divergence-based objective function. We show the advantages of SKMS by evaluating its performance on various synthetic and real datasets while comparing with state-of-the-art semi-supervised clustering algorithms.
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http://dx.doi.org/10.1109/TPAMI.2013.190 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Modelling of Cognitive Processes, Berlin Institute of Technology, Berlin 10587, Germany.
Neuronal processing of external sensory input is shaped by internally generated top-down information. In the neocortex, top-down projections primarily target layer 1, which contains NDNF (neuron-derived neurotrophic factor)-expressing interneurons and the dendrites of pyramidal cells. Here, we investigate the hypothesis that NDNF interneurons shape cortical computations in an unconventional, layer-specific way, by exerting presynaptic inhibition on synapses in layer 1 while leaving synapses in deeper layers unaffected.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Patients with ulcerative colitis (UC) have a higher risk of developing colorectal cancer (CRC), however, the metabolic shifts during the UC-to-CRC transition remain elusive. In this study, an AOM-DSS-induced three-stage colitis-associated colorectal cancer (CAC) model is constructed and targeted metabolomics analysis and pathway enrichment are performed, uncovering the metabolic changes in this transition. Spatial metabolic trajectories in the "normal-to-normal adjacent tissue (NAT)-to-tumor" transition, and temporal metabolic trajectories in the "colitis-to-dysplasia-to-carcinoma" transition are identified through K-means clustering of 74 spatially and 77 temporally differential metabolites, respectively.
View Article and Find Full Text PDFEcol Evol
January 2025
Pabellón Nacional de la Biodiversidad, Departamento de Zoología, Instituto de Biología Universidad Nacional Autónoma de México Ciudad de México Mexico.
Habitat loss threatens biodiversity worldwide being particularly detrimental in tropical rainforests where a cumulative deforestation expands for decades. Tropical rainforests harbor a rich mammal diversity with a wide range of species using different habitats, ranging from forest-dwelling to arboreal species. Recent techniques such as camera trapping have proven to be useful to study the ecology of arboreal mammals.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Division of Vector Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico.
Mosquito-transmitted viruses such as dengue are a global and growing public health challenge. Without widely available vaccines, mosquito control is the primary tool for fighting the spread of these viruses. New mosquito control technologies are needed to complement existing methods, given current challenges with scalability, acceptability, and effectiveness.
View Article and Find Full Text PDFOpen Forum Infect Dis
January 2025
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Background: Arboviruses, including Dengue (DENV), Zika, and chikungunya, cause recurrent outbreaks of varying intensity in tropical countries. This study aimed to investigate other arboviruses, including Zika and chikungunya, in patients clinically suspected of Dengue and to characterize the circulating Dengue serotypes and genotypes in Northern Vietnam from 2020 to 2022. To date, information on this topic in the region has been limited.
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