We introduce a new discrepancy measure between two distributions that gives an indication on their similarity. The new measure, termed the Perturbed Variation (PV), gives an intuitive interpretation of similarity; it optimally perturbs the distributions so that they best fit each other. The PV is defined between continuous and discrete distributions, and can be efficiently estimated from samples. We provide bounds on the convergence of the estimated score to its distributional value, as well as robustness analysis of the PV to outliers. A number of possible applications of the score are presented, and its ability to detect similarity is compared with that of other known measures on real data. We also present a new visual tracking algorithm based on the PV, and compare its performance with known tracking algorithms.
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http://dx.doi.org/10.1109/TPAMI.2015.2404836 | DOI Listing |
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January 2025
Key Laboratory of Multiscale Spin Physics, Ministry of Education, School of Physics and Astronomy, Beijing Normal University, Beijing, 100875, P. R. China.
The etch-engineering is a feasible avenue to tailor the layer number and morphology of 2D layered materials during the chemical vapor deposition (CVD) growth. However, less reports strengthen the etch-engineering used in the fabrication of high-quality transition metal dichalcogenide (TMD) materials with tunable layers and desirable morphologies to improve their prominent performance in electronic and optoelectronic devices. Here, an etching-and-growth coexistence method is reported to directly synthesize high-quality, high-symmetric MoS bilayers with versatile morphologies via CVD.
View Article and Find Full Text PDFNat Rev Genet
January 2025
Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA.
Traditionally, differences among individuals have been divided into genetic and environmental causes. However, both types of variation can underlie regulatory changes in gene expression - that is, epigenetic changes - that persist across cell divisions (developmental differentiation) and even across generations (transgenerational inheritance). Increasingly, epigenetic variation among individuals is recognized as an important factor in human diseases and ageing.
View Article and Find Full Text PDFNeurology
February 2025
Department of Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Background And Objectives: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme that regulates folate and homocysteine metabolism. Genetic variation in has been implicated in cerebrovascular disease risk, although research in diverse populations is lacking. We thus aimed to investigate the effect of genetically predicted MTHFR activity on risk of ischemic stroke (IS) and its main subtypes using a multiancestry Mendelian randomization (MR) approach.
View Article and Find Full Text PDFElectromagn Biol Med
January 2025
Department of Applied Mathematics, University of Calcutta, Kolkata, India.
The current investigation explores tri-hybrid mediated blood flow through a ciliary annular model, designed to emulate an endoscopic environment. The human circulatory system, driven by the metachronal ciliary waves, is examined in this study to understand how ternary nanoparticles influence wave-like flow dynamics in the presence of interfacial nanolayers. We also analyze the effect of an induced magnetic field on Ag-Cu-/blood flow within the annulus, focusing on thermal radiation, heat sources, buoyancy forces and ciliary motion.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Computational Health, Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany.
Advancements in high-throughput screenings enable the exploration of rich phenotypic readouts through high-content microscopy, expediting the development of phenotype-based drug discovery. However, analyzing large and complex high-content imaging screenings remains challenging due to incomplete sampling of perturbations and the presence of technical variations between experiments. To tackle these shortcomings, we present IMage Perturbation Autoencoder (IMPA), a generative style-transfer model predicting morphological changes of perturbations across genetic and chemical interventions.
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