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Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides.
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Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.
View Article and Find Full Text PDFComputational and molecular insights on non-synonymous SNPs associated with human RAAS genes: Consequences for Hypertension vulnerability.
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Department of Bioinformatics, Pharmacogenomics and CADD Lab, Alagappa University, Karaikudi, Tamil Nadu, India. Electronic address:
Hypertension is the foremost modifiable risk factor for cardiovascular and renal diseases, and overall mortality on a global scale. Genetic variants have the potential to alter an individual's drug responses. In the present study, we employed a comprehensive computational analysis to evaluate the structural and functional implications of deleterious missense variants to examine the influence of RAAS genes such as AT1R, AT2R, and MasR on susceptibility to hypertension.
View Article and Find Full Text PDFUndiagnosed Lymphoma Detected During Routine Histocompatibility Crossmatch: Three Case Reports.
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Histocompatibility and Infectious Disease Testing Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI. Electronic address:
Unexpected transmission of donor-derived diseases, including infections and malignancies, through organ transplantation are occasionally observed and reported. Subclinical, or otherwise undiagnosed, hematological malignancies in potential donors are rare events and typically not identifiable via standard donor evaluation or laboratory testing. Flow cytometric crossmatching (FCXM) is a specialized assay routinely performed in clinical histocompatibility laboratories for the evaluation of immunological compatibility between the recipients and the organ donors through the detection of donor-specific antibodies.
View Article and Find Full Text PDFUnraveling the mystery of citrate transporters in Alzheimer's disease: An updated review.
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Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430. Electronic address:
A key molecule in cellular metabolism, citrate is essential for lipid biosynthesis, energy production, and epigenetic control. The etiology of Alzheimer's disease (AD), a progressive neurodegenerative illness marked by memory loss and cognitive decline, may be linked to dysregulated citrate transport, according to recent research. Citrate transporters, which help citrate flow both inside and outside of cells, are becoming more and more recognized as possible participants in the molecular processes underlying AD.
View Article and Find Full Text PDFTeaching the Science of Life: A Multidisciplinary Educational Approach to Reproductive Technology Debates Through the Lens of Developmental Biology.
Dev Biol
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Department of Biological Sciences, School of Arts and Sciences, Lebanese American University (LAU), Byblos, Lebanon. Electronic address:
In vitro fertilization, cryopreservation and pre-implantation genetic testing are transformative reproductive technologies offering hope for individuals facing fertility challenges. Scientifically, understanding the science of developmental biology is essential for comprehending the mechanisms and implications of these technologies. In embryological sciences, biological perspectives identify life as a series of developmental stages ranging from conception to viability, each potentially representing a different 'beginning' of life.
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