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Integrated multidisciplinary analysis of mobile digital radiographic acquisitions of the mummies of the hermits from the Sanctuary of Madonna della Corona (Trentino-Alto Adige, Italy - 17th to 19th century CE).
Front Med (Lausanne)
January 2025
CROP - Centre of Research in Osteoarchaeology and Paleopathology, Biotechnologies and Life Sciences Department (DBSV), University of Insubria, Varese, Italy.
Paleoradiology has become a standard diagnostic method in the study of mummified or embalmed bodies. Among the various available techniques, computed tomography valuing for its ability to provide detailed information. However, computed tomography equipment is not always accessible to research teams, cannot be easily transported to all conservation sites, and raises health concerns.
View Article and Find Full Text PDFImmuno-oncology in the daily practice.
Curr Opin Oncol
January 2025
Gustave Roussy Departement Interdisciplinaire de Soins de Support aux Patients en Onco-hematologie, Villejuif, France.
Purpose Of Review: Immune checkpoint inhibitors (ICI) have become an integral part of oncology treatment. ICI currently has approval for more than thirty tumor types with proven efficacy. However, ICI can expose patients to inflammatory side effects, such as immuno-related adverse events (irAE).
View Article and Find Full Text PDFAssessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using .
bioRxiv
January 2025
Nicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Few of the many chemicals that regulatory agencies are charged with assessing for risk have been carefully tested for developmental neurotoxicity (DNT). To speed up testing efforts, as well as to reduce the use of vertebrate animals, great effort is being devoted to alternate laboratory models for testing DNT. A major mechanism of DNT is altered neuronal architecture resulting from chemical exposure during neurodevelopment.
View Article and Find Full Text PDFSaponins Effect on Human Insulin Amyloid Aggregation.
Biomolecules
December 2024
Department of Life and Environmental Sciences, Marche Polytechnic University, I-60131 Ancona, Italy.
The misfolding and amyloid aggregation of proteins have been attracting scientific interest for a few decades, due to their link with several diseases, particularly neurodegenerative diseases. Proteins can assemble and result in insoluble aggregates that, together with intermediate oligomeric species, modify the extracellular environment. Many efforts have been and are devoted to the search for cosolvents and cosolutes able to interfere with amyloid aggregation.
View Article and Find Full Text PDFHow will independent prescribing affect wellbeing and career progression for the pharmacists of tomorrow?
Future Healthc J
December 2024
School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
Pharmacist independent prescriber numbers continue to increase. In 2025/2026, independent prescribing will be integrated into the foundation year of pharmacy training, which will see a surge of pharmacists with the independent prescribing annotation on the General Pharmaceutical Council register. With increased responsibility and expectation from early careers pharmacists, the risk of burnout may be higher, and we could potentially see an increase in the number of individuals leaving the profession.
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