AI Article Synopsis
- This study explored the link between specific genetic variations in the renin-angiotensin system and essential hypertension in people from Burkina Faso, using a case-control design with 202 hypertensive patients and 204 matched controls.
- The research found that while two polymorphisms (AGT 235M/T and AT1R 1166A/C) showed no association with hypertension, the ACE I/D polymorphism had significantly different genotype frequencies between the groups, with the DD genotype being more prevalent in hypertensive patients.
- Key risk factors identified included the DD genotype of the ACE gene, older age, obesity, dyslipidemia, and alcohol consumption, indicating that the DD genotype is a significant predictor of hypertension susceptibility.
Article Abstract
Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10(-4)). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553326 | PMC |
| http://dx.doi.org/10.1155/2015/979631 | DOI Listing |
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