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Background: Our team recently published outcomes of a novel technique for the administration of Collagenase Clostridium histolyticum (CCH), which resulted in improved curvature outcomes and reduced number of CCH injections required.

Aim: To provide a detailed and illustrated description of our CCH-administration technique.

Methods: A descriptive summary is provided of the technique, including drug administration, protocol modifications, and post-treatment protocols.

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Introduction: Intralesional collagenase (CCH) injection is an effective intervention for treatment of Peyronie's disease (PD). While CCH efficacy has been demonstrated in White populations, little is known about treatment efficacy in Black and Hispanic populations.

Methods: This study examined efficacy of intralesional CCH in a racially diverse population in a large integrated health care system over 15 years.

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Therapy for Dupuytren's Disease: Collagenase Therapy-A Long-Term Follow-Up Study.

Life (Basel)

October 2024

Department of Hand, Plastic and Aesthetic Surgery, LMU Klinikum, Ziemssenstraße 5, 80336 Munich, Germany.

Background: Dupuytren's disease (DD) is a systemic connective tissue disorder of the palm. It particularly affects men of Northern European or Caucasian origin over the age of 55. In addition to the classical surgical therapy via limited fasciectomy, Dupuytren's contracture can also be treated minimally invasively.

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A review of Peyronie's disease insurance coverage.

Sex Med

October 2024

Division of Plastic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States.

Article Synopsis
  • Peyronie's disease (PD) leads to penile curvature and related issues, with various treatment options available including surgery, devices, and medications.
  • A study examined insurance coverage for these treatments across top US insurers, finding only 54% had clear policies on PD.
  • The most commonly covered treatment was collagenase injections, while shock wave therapy was universally denied, highlighting significant gaps in coverage and suggesting a need for better alignment with clinical guidelines.
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Collagenase Injection versus Limited Fasciectomy for Dupuytren's Contracture.

N Engl J Med

October 2024

From the Academic Team of Musculoskeletal Surgery, Undercroft, Leicester General Hospital, University Hospitals of Leicester NHS Trust (J.D., M.A., J.J.), Leicester (J.C.), the York Trials Unit (P.T., C.A., C.W., S.J., S.B., L.G.F., C.N.K., M.W., A.K., C.E.H., D.T.) and the Department of Health Sciences (Q.W.), University of York, York, the University of Nottingham, Nottingham (P.L.), University Hospitals of Derby and the Burton NHS Trust, Derby (N.J., L.B.), the Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham (M.C.), and the University Hospital Southampton NHS Foundation Trust, Southampton (D.W.) - all in the United Kingdom.

Article Synopsis
  • - The study compares the effectiveness of two treatments for Dupuytren's contracture: collagenase injection and limited fasciectomy, using a randomized controlled trial with 672 participants
  • - The main measurement tool used was the Patient Evaluation Measure-Hand Health Profile (PEM), where scores range from 0 to 100, with higher scores indicating worse hand health; results showed a mean score of 17.8 for the collagenase group and 11.9 for the limited-fasciectomy group at 1 year
  • - The findings concluded that collagenase injection was not as effective as limited fasciectomy after one year, with fewer complications reported in the collagenase group (1.8%) compared to the limited-fasc
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