Novel Mediators of Adipose Tissue and Muscle Crosstalk.

Curr Obes Rep

Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center (DDZ), Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Published: December 2015

The crosstalk between adipose tissue and skeletal muscle has gained considerable interest, since this process, specifically in obesity, substantially drives the pathogenesis of muscle insulin resistance. In this review, we discuss novel concepts and targets of this bidirectional organ communication system. This includes adipo-myokines like apelin and FGF21, inflammasomes, autophagy, and microRNAs (miRNAs). Literature analysis shows that the crosstalk between fat and muscle involves both extracellular molecules and intracellular organelles. We conclude that integration of these multiple crosstalk elements into one network will be required to better understand this process.

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Source
http://dx.doi.org/10.1007/s13679-015-0174-7DOI Listing

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