The detection of psychopharmacological properties of 8 synthetic substances derived from barbituric didn't allow to consider the existence of well characterised psychotropic properties, particularly hypnotical, but only antalgic and sedative effects (or stimulating activity very low). If the presence of a benzyl substituent can confer an affinity for the nervous central system superior to the one developed when an allyl rest is in the same position, the presence of an OH or OCH3 in other place inverse the sedative character in stimulant potentiality.
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Clin EEG Neurosci
January 2025
Department of Biostatistics, Istanbul University, Faculty of Medicine, Istanbul, Turkey.
Quantitative electroencephalography (qEEG) data can facilitate the monitoring of treatment progress and the evaluation of therapeutic responses in patients with Major Depressive Disorder (MDD). This study aims to compare the qEEG data of MDD patients and healthy controls, both before and after treatment, to assess the effect of treatment response on neural activity. A total of 72 patients, aged 18-60, who had not used any psychopharmacological medication for at least two weeks, were included in the study.
View Article and Find Full Text PDFSleep Med
December 2024
Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium; Scientific Initiative of Neuropsychiatric and Psychopharmacological Studies (SINAPS), University Psychiatric Hospital Campus Duffel, Rooienberg 19, 2570, Duffel, Belgium.
Background: Fragmented rapid eye movement (REM) sleep disrupts the overnight resolution of emotional distress, a process crucial for emotion regulation. Emotion dysregulation, which is common across psychiatric disorders, is often associated with sleep disturbances. This systematic review explores how REM sleep and nightmares affect emotion processing and regulation in individuals with psychiatric disorders where emotion dysregulation is a key concern, suggesting novel sleep-related treatment pathways.
View Article and Find Full Text PDFJ Multidiscip Healthc
December 2024
Hospices Civils de Lyon, Lyon, France.
Purpose: Psychopharmacology prescriptions are complex, partly due to the complexity of the relationship between diagnosis and its etiology, as well as the iatrogenic impact on symptomatology. Many multidisciplinary tools exist to optimize their management and improve evidence-based practice. However, their multidisciplinary integration seems to be a challenge.
View Article and Find Full Text PDFPsychiatry Res
December 2024
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.
The Experience Sampling Method (ESM) is increasingly used to validate and assess treatment effects. We conducted a systematic review to update, and extend, the previous review by Bos et al. (2015), by performing literature searches in PubMed, PsycInfo, and EMBASE.
View Article and Find Full Text PDFBrain Behav Immun
December 2024
Scientific Initiative for Neuropsychiatric and Psychopharmacological Studies (SINAPS), University Psychiatric Hospital Campus Duffel (UPCD), Rooienberg 19, 2570 Duffel, Belgium; Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Campus Drie Eiken, S.003, Universiteitsplein 1, 2610 Wilrijk, Belgium.
In a letter critiquing our manuscript, Takefuji highlights general pitfalls in machine learning, without directly engaging with our study. The comments provide generic advice rather than a specific critique of our methods or findings. Despite raising important topics, the concerns reflect standard risks in machine learning, which we were aware of and explicitly addressed in our analyses.
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