The synthesis of isoindolinones via copper-catalyzed sp(3) C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5b02235 | DOI Listing |
Publication Analysis
Top Keywords
copper-catalyzed sp3
8
sp3 c-h
8
c-h aminative
4
aminative cyclization
4
cyclization 2-alkyl-n-arylbenzamides
4
2-alkyl-n-arylbenzamides approach
4
approach synthesis
4
synthesis n-aryl-isoindolinones
4
n-aryl-isoindolinones synthesis
4
synthesis isoindolinones
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!