AI Article Synopsis
- Twenty new polyoxygenated labdane diterpenoids were extracted from Leonurus macranthus and identified using various spectroscopic techniques.
- The structures of two specific compounds, macranthin A and its derivative, were confirmed through X-ray analysis and a specific molecular method.
- Some of these compounds demonstrated the ability to inhibit nitric oxide production in activated microglial cells, with varying potency levels.
Article Abstract
Twenty new polyoxygenated labdane diterpenoids (1-20) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of macranthin A (1) and 6-O-deacetylmacranthin A (2) were determined by single-crystal X-ray crystallographic analysis and a modified Mosher's method, respectively. Compounds 1-9, 12, 14, and 19 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 10.0-63.7 μM.
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| http://dx.doi.org/10.1021/acs.jnatprod.5b00635 | DOI Listing |
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