AI Article Synopsis
- The study focuses on cloning and analyzing the cDNA for human prointerleukin-1 alpha and prointerleukin-1 beta.
- No amino acid changes were detected in the comparison of proIL-1 alpha and proIL-1 beta cDNAs with previously published sequences.
- Nucleotide changes were observed only in the 3'-nontranslated region of proIL-1 beta, leading to the suggestion of allelic variants for interleukin genes.
Article Abstract
The data are presented on the cloning and structural analysis of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta (proIL-1 alpha and proIL-1 beta). The nucleotide sequences of proIL-1 alpha and proIL-1 beta cDNAs have been compared with the sequences published earlier. The nucleotide changes resulting in the aminoacid changes of the protein were not found. Some nucleotide changes were identified within the 3'-nontranslated region of the proIL-1 beta cDNA. The existence of the allelic variants for interleukin genes registered only on the gene level has been supposed.
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