AI Article Synopsis
- A variety of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-diones were created and tested for their effects on cell growth and death using specific laboratory assays.
- Compounds including 6g showed significant promise by effectively inducing cancer cell death and impacting important signaling pathways like ERK1/2 and p38.
- The findings suggest that these compounds have potential as anticancer agents, prompting further exploration and development.
Article Abstract
A series of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-diones were synthesized and evaluated using the cell proliferations, apoptosis and NCI-60 cell panel assays. Also, the signaling pathways that account for their activities were investigated. Compounds 2, 3, 4a, 4d, 4f, 4i, 4k, 5b, 5c, 5d, 5f, 5g, 6b, 6c, 6d, 6e, 6g, 7a and 7g were selected by NCI. Among the tested compounds, 6g appeared to be the most active compound of this series that not only induced apoptosis in DU-145 cancer cells but also attenuated the ERK1/2 and p38 signaling pathways. All test compounds exhibited diverse cytostatic and cytotoxic activities that warrant further development as potential anticancer agents.
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| http://dx.doi.org/10.1016/j.ejmech.2015.07.052 | DOI Listing |
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