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Genetically Engineered Bacterial Ghosts as Vaccine Candidates Against Infection.
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Laboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia.
Bacterial ghosts (BGs), non-living empty envelopes of bacteria, are produced either through genetic engineering or chemical treatment of bacteria, retaining the shape of their parent cells. BGs are considered vaccine candidates, promising delivery systems, and vaccine adjuvants. The practical use of BGs in vaccine development for humans is limited because of concerns about the preservation of viable bacteria in BGs.
View Article and Find Full Text PDFChitosan- and sodium alginate-coated dendritic mesoporous organosilica nanoparticles improve pesticide adhesion on leaves and enable dual-stimulus-responsive release.
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January 2025
Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address:
During the application of most conventional pesticides, a significant proportion is lost through rain wash-off and leaf rolling, leading to reduced actual utilization efficiency. In this paper, aminated dendritic mesoporous organosilicon nanoparticles (DMONs-NH) were synthesized via a one-pot method and used as carriers. Carbendazim (CBZ) was then encapsulated within DMONs-NH through hydrogen bonding and electrostatic interactions.
View Article and Find Full Text PDFMicroenvironment-responsive sodium alginate hydrogel loaded with MnO and pachymic acid for the treatment of gastric ulcer.
Biomed Pharmacother
January 2025
Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing, China. Electronic address:
Gastric ulcer (GU), a common digestive system disorder in clinical practice, often arises from excessive alcohol consumption and other factors that irritate the gastric mucosa. Effective treatment of GU remains challenging due to the poor targeting, limited efficacy, and significant side effects associated with current therapeutic approaches. To address these limitations, we developed a microenvironment-responsive hydrogel composed of sodium alginate (SA) and chitosan (CS), incorporating MnO nanoparticles and pachymic acid (PA).
View Article and Find Full Text PDFAccounting for the role of the gastro-intestinal tract in the ammonia and urea-N dynamics of freshwater rainbow trout on long-term satiation feeding.
J Exp Biol
January 2025
Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
The contribution of the gut to the ingestion, production, absorption, and excretion of the extra ammonia and urea-N associated with feeding ("exogenous" fraction) has received limited prior attention. Analysis of commercial pellet food revealed appreciable concentrations of ammonia and urea-N. Long term satiation-feeding increased whole trout ammonia and urea-N excretion rates by 2.
View Article and Find Full Text PDFOxygen Reduction Reaction Catalysts for Zinc-Air Batteries Featuring Single Cobalt Atoms in a Nitrogen-Doped 3D-Interconnected Porous Graphene Framework.
Small
January 2025
College of Material Science and Engineering, Hunan University, Changsha, Hunan, 410082, China.
Single-atom catalysts (SACs) with high activity and efficient atom utilization for oxygen reduction reactions (ORRs) are imperative for rechargeable Zinc-air batteries (ZABs). However, it is still a prominent challenge to construct a noble-metal-free SAC with low cost but high efficiency. Herein, a novel nitrogen-doped graphene (NrGO) based SAC, immobilized with atomically dispersed single cobalt (Co) atoms (Co-NrGO-SAC), is reported for ORRs.
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