AI Article Synopsis
- Micrometam C is a new marine compound derived from the mangrove plant Micromelum falcatum, which was studied for its anti-inflammatory effects.
- It showed a significant reduction in immune cell migration during inflammation in genetically modified zebrafish and decreased harmful reactive oxygen species (ROS) in both zebrafish and macrophage cells.
- The compound also helped restore key antioxidant levels and inhibited specific inflammatory pathways, suggesting that its protective effects are largely due to its antioxidant properties.
Article Abstract
Micrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found that micrometam C significantly suppressed the migration of immune cells in tail-cutting-induced inflammation in transgenic zebrafish and reduced lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) in both zebrafish and macrophages. In addition, micrometam C also restored LPS-induced reduction of endogenous antioxidants, such as catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD). The protective effects of micrometam C were in parallel to its inhibition of NADPH oxidase and nuclear factor-kappa-binding (NF-κB) activity. Thus, the present results demonstrate that micrometam C protects against LPS-induced inflammation possibly through its antioxidant property.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584342 | PMC |
| http://dx.doi.org/10.3390/md13095593 | DOI Listing |
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