A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Comparative cellular biogerontology: Where do we stand? | LitMetric

Comparative cellular biogerontology: Where do we stand?

Exp Gerontol

Department of Biological Sciences, Sam Houston State University Huntsville, TX USA 77340. Electronic address:

Published: November 2015

Due to the extreme variation in life spans among species, using a comparative approach to address fundamental questions about the aging process has much to offer. For example, maximum life span can vary by as much as several orders of magnitude among taxa. In recent years, using primary cell lines cultured from species with disparate life spans and aging rates has gained considerable momentum as a means to dissect the mechanisms underlying the variation in aging rates among animals. In this review, we reiterate the strengths of comparative cellular biogerontology, as well as provide a survey of the current state of the field. By and large this work sprang from early studies using cell lines derived from long-lived mutant mice. Specifically, they suggested that an enhanced resistance to cellular stress was strongly associated with increased longevity of select laboratory models. Since then, we and others have shown that the degree of stress resistance and species longevity is also correlated among cell lines derived from free-living populations of both mammals and birds, and more recent studies have begun to reveal the biochemical and physiological underpinnings to these differences. The continued study of cultured cell lines from vertebrates with disparate life spans is likely to provide considerable insight toward unifying mechanisms of longevity assurance.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2015.08.018DOI Listing

Publication Analysis

Top Keywords

cell lines
16
life spans
12
comparative cellular
8
cellular biogerontology
8
disparate life
8
aging rates
8
lines derived
8
biogerontology stand?
4
stand? extreme
4
extreme variation
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!