AI Article Synopsis
- Advances in synthetic biology and biofabrication enable the development of advanced cellular networks that can be effectively connected and manipulated.
- The proposed 'bioproduction breadboard' platform will feature isolated cell groups responsible for producing specific products, along with devices for capturing those products, all functioning through standardized inputs for easy integration.
- This system aims to enhance bioproduction efficiency by allowing both direct user control and automatic self-regulation within the interconnected cell populations, facilitating the creation of innovative biochemical pathways.
Article Abstract
With advances in synthetic biology and biofabrication, cellular networks can be functionalized and connected with unprecedented sophistication. We describe a platform for the creation of a 'bioproduction breadboard'. This would consist of physically isolated product-producing cell populations, product capture devices, and other unit operations that function as programmed in place, using unique, orthogonal inputs. For product synthesis, customized cell populations would be connected through standardized, generic inputs allowing 'plug and play' functionality and primary, user-mediated regulation. In addition, through autonomous pathway redirection and balancing, the cells themselves would provide secondary, self-directed regulation to optimize bioproduction. By leveraging specialization and division of labor, we envision diverse cell populations linked to create new pathway designs.
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| http://dx.doi.org/10.1016/j.copbio.2015.08.017 | DOI Listing |
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