Production of infectious HIV-1 particles requires viral envelope (Env) glycoprotein incorporation. Although, the precise mechanism remains elusive, interaction between Env and the matrix (MA) domain of Gag plays a central role. Work by Mu and colleagues demonstrates how the Env-MA interaction regulates gag mRNA stability and Gag expression levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tim.2015.08.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
bioRxiv
December 2024
Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Acute myeloid leukemias (AMLs) have an overall poor prognosis with many high-risk cases co-opting stem cell gene regulatory programs, yet the mechanisms through which this occurs remain poorly understood. Increased expression of the stem cell transcription factor, MECOM, underlies one key driver mechanism in largely incurable AMLs. How MECOM results in such aggressive AML phenotypes remains unknown.
View Article and Find Full Text PDFThinking beyond substances: Why behavioral "addiction" research must move past substance use disorder paradigms.
J Psychopathol Clin Sci
January 2025
Department of Psychology, Center on Alcohol, Substance Use, and Addictions (CASAA), University of New Mexico.
In this viewpoint article, the authors contend that behavioral addiction (BA) research must move past substance use disorder paradigms. Under the most liberal definitions of BA, activities such as eating, exercise, work, smartphone use, and a litany of others could all become addictions. Abundant clinical evidence shows that people may frequently engage in behaviors in ways that become impairing.
View Article and Find Full Text PDFMulti-conflict islands are a widespread trend within Serratia spp.
Cell Rep
December 2024
Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford, Surrey, UK. Electronic address:
Bacteria carry numerous anti-phage systems in "defense islands" or hotspots. Recent studies have delineated the content and boundaries of these islands in various species, revealing instances of islands that encode additional factors, including antibiotic resistance genes, stress genes, type VI secretion system (T6SS)-dependent effectors, and virulence factors. Our study identifies three defense islands in the Serratia genus with a mixed cargo of anti-phage systems, virulence factors, and different types of anti-bacterial modules, revealing a widespread trend of co-accumulation that extends beyond T6SS-dependent effectors to colicins and contact-dependent inhibition systems.
View Article and Find Full Text PDFProteolysis of host DEAD-box RNA helicase by potyviral proteases activates plant immunity.
New Phytol
November 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Article Synopsis
- The mechanisms by which plant viral proteases interact with host proteins and influence virus-host dynamics are not fully understood, particularly in potyviruses, the largest group of RNA viruses affecting plants.
- Research shows that the protease NIa-Pro from the turnip mosaic virus (TuMV) is crucial for inducing hypersensitive cell death in the plant Nicotiana benthamiana by targeting and degrading the host protein DBP5.
- Additionally, findings reveal that the TuMV-encoded nuclear inclusion b can mitigate NIa-Pro-induced cell death by interacting with DBP5, suggesting complex roles for viral proteases in disrupting host immunity.
Tobacco industry narratives of e-cigarette use in the UK: a qualitative framing analysis.
Health Promot Int
December 2024
University of Cambridge, Trinity Lane, CB2 1TN, UK.
Public health actors have expressed concerns over the entry of the tobacco industry into the UK e-cigarette market. It is important to be aware of the tobacco industry's involvement and stated aims for e-cigarettes in the UK, given their historical attempts to divert attention from and escape responsibility for the harms caused by combustible cigarettes. The use of e-cigarettes amongst young people in the UK has remained constant, despite the law prohibiting sales to adolescents and claims by manufacturers and others that they are designed solely as a tool to quit smoking.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!