The rapid collapse of a polymer, due to external forces or changes in solvent, yields a long-lived "crumpled globule." The conjectured fractal structure shaped by hierarchical collapse dynamics has proved difficult to establish, even with large simulations. To unravel this puzzle, we study a coarse-grained model of in-falling spherical blobs that coalesce upon contact. Distances between pairs of monomers are assigned upon their initial coalescence, and do not "equilibrate" subsequently. Surprisingly, the model reproduces quantitatively the dependence of distance on segment length, suggesting that the slow approach to scaling is related to the wide distribution of blob sizes.
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http://dx.doi.org/10.1103/PhysRevLett.115.088303 | DOI Listing |
Proc Biol Sci
January 2025
Royal Botanic Garden Edinburgh, Edinburgh EH3 5LR, UK.
The two main extensions of rain forest in South America are the Amazon (Amazônia) and the Atlantic rain forest (Mata Atlântica), which are separated by a wide 'dry diagonal' of seasonal vegetation. We used the species-rich tree genus to test if Amazônia-Mata Atlântica dispersals have been clustered during specific time periods corresponding to past, humid climates. We performed hybrid capture DNA sequencing of 810 nuclear loci for 453 accessions representing 164 species that included 62% of Mata Atlântica species and estimated a dated phylogeny for all accessions using maximum likelihood, and a species-level tree using coalescent methods.
View Article and Find Full Text PDFFront Chem
January 2025
Jiangxi Copper Technology Institute Co., Ltd, Nanchang, Jiangxi, China.
Introduction: Whether in industrial production or daily life, froth plays an important role in many processes. Sometimes, froth exists as a necessity and is also regarded as the typical characteristic of products, e.g.
View Article and Find Full Text PDFSyst Biol
January 2025
School of Life Sciences and Department of Statistics, University of Warwick, UK.
The vast majority of pathogen phylogenetic studies do not consider the possibility of multiple merger events being present, where a single node of the tree leads to more than two descendent branches. These events are however likely to occur when studying a relatively small population or if there is high variability in the reproductive chances. Here we consider the problem of detecting the presence of multiple mergers in the context of dating a phylogeny, that is determining the date of each of the nodes.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
January 2025
Microsystems Group, School of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
The increasing demand for processing large volumes of data for machine learning (ML) models has pushed data bandwidth requirements beyond the capability of traditional von Neumann architecture. In-memory computing (IMC) has recently emerged as a promising solution to address this gap by enabling distributed data storage and processing at the micro-architectural level, significantly reducing both latency and energy. In this article, we present In-Memory comPuting architecture based on Y-FlAsh technology for Coalesced Tsetlin machine inference (IMPACT), underpinned on a cutting-edge memory device, Y-Flash, fabricated on a 180 nm complementary metal oxide semiconductor (CMOS) process.
View Article and Find Full Text PDFJ Pathol Inform
January 2025
Harvard Medical School, Boston, MA, United States of America.
Objective: Thrombocytopenia is a common complication of hematopoietic stem-cell transplantation (HSCT), though many patients will become immune refractory to platelet transfusions over time. We built and evaluated an electronic health record (EHR)-integrated, standards-based application that enables blood-bank clinicians to match platelet inventory with patients using data previously not available at the point-of-care, like human leukocyte antigen (HLA) data for donors and recipients.
Materials And Methods: The web-based application launches as an EHR-embedded application or as a standalone application.
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