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Evaluating the impact of gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment.
J Turk Ger Gynecol Assoc
December 2024
Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Objective: Polycystic ovary syndrome (PCOS) is prevalent among reproductive-aged women and is categorized by hormonal imbalances, irregular menstrual cycles, and challenges with fertility. PCOS affects approximately 3.6% of women globally, with prevalence varying by region.
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- A combination of mifepristone and misoprostol is recommended for inducing labor, with specific dosing guidelines based on gestation week (Grade B).
- For women with a history of previous cesarean sections, the safety of labor induction is uncertain, especially for those with multiple or atypical scars (Grade D).
- Parents should receive comprehensive discussions about their birth options (vaginal vs. cesarean), with a focus on the physical and psychological impacts, while also ensuring a supportive environment for grief (Grade C).
Risk Stratification in Older Intensively Treated Patients With AML.
J Clin Oncol
December 2024
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Article Synopsis
- - The study focuses on older patients (over 60 years) with acute myeloid leukemia (AML) and aims to create a prognostic model to identify those who would benefit from intensive chemotherapy and stem cell transplantation.
- - Researchers analyzed data from 1,910 patients, using a random survival forest to evaluate clinical and genetic factors associated with overall survival, resulting in the identification of four distinct survival groups based on nine variables.
- - The newly developed AML60+ classification shows improved prognostic accuracy and indicates that intermediate- and very poor-risk patients may benefit from allogeneic hematopoietic cell transplantation, potentially guiding treatment decisions for older adults with AML.
Comparative Analysis of Two NGS-Based Platforms for Product-of-Conception Karyotyping.
Genes (Basel)
August 2024
Division of Molecular Genetics, Center for Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Article Synopsis
- Cytogenetic analysis of the product of conception (POC) is crucial for identifying chromosomal abnormalities, which can guide preimplantation genetic testing; traditional G-staining methods often fail due to issues with cell culture.* -
- Recent research suggests that low-coverage whole-genome sequencing (lcWGS) using next-generation sequencing (NGS) is a promising alternative for POC analysis, with two NGS protocols showing equivalent results across 20 samples.* -
- However, caution is advised when interpreting data related to the X chromosome, as some anomalies may stem from technical artifacts rather than true genetic conditions, indicating the need for careful analysis in NGS applications.*
Morphologic, Proliferative, and Cytogenetic Changes during In Vitro Propagation of Cat Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.
Animals (Basel)
August 2024
Unidad de Inmunología e Inmunoterapia, Departamento de Patobiología, Facultad de Veterinaria, Universidad de la República (UdelaR), Montevideo 13000, Uruguay.
Stem cell therapy in cat patients needs a high quantity of mesenchymal stromal/stem cells (MSCs) requiring in vitro propagation under culture conditions which may potentially impact cellular characteristics and genetic stability. This study aimed to assess the in vitro characteristics and cytogenetic stability of cat adipose tissue-derived MSCs (cAT-MSCs). For this purpose, morphological features, clonogenic potential, and proliferative capacity of cAT-MSCs were assessed at passages 2 (P), P, and P.
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