Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.349.6252.1134 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anti-PD-L1 envafolimab combined with anti-VEGF suvemcitug in pretreated solid tumors and hepatocellular carcinoma: an open-label phase II study with safety run-in stage.
Invest New Drugs
January 2025
Department of Internal Medicine, Jilin Cancer Hospital, Changchun, China.
Background: Immune checkpoint inhibitors (ICIs) combined with anti-vascular endothelial growth factor (VEGF) have been the standard first-line treatment of hepatocellular carcinoma (HCC). However, the efficacy of this combination in post-line treatment is still unknown. This study aimed to evaluate the efficacy and safety of the combination of anti-PD-L1 envafolimab and novel humanized anti-VEGF suvemcitug as second-line treatment for patients with HCC.
View Article and Find Full Text PDFMyristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages.
Elife
January 2025
Department of Microbiology and Immunology, Stanford University, Stanford, United States.
The primary cilium is a microtubule-based organelle that cycles through assembly and disassembly. In many cell types, formation of the cilium is initiated by recruitment of ciliary vesicles to the distal appendage of the mother centriole. However, the distal appendage mechanism that directly captures ciliary vesicles is yet to be identified.
View Article and Find Full Text PDFDecision-making and climbing performance under time constraints in Olympic bouldering.
J Sports Sci
January 2025
Complexité, Innovation & Activités Motrices et Sportives (CIAMS), Sciences et Techniques des Activités Physiques et Sportives, Université d´Orléans, Orléans, France.
Kahneman's dual-process model postulates that two systems are involved in decision-making: slow thinking, defined as analytical processing of information, and fast thinking, where decisions emerge from intuitive, automatic responses. Climbers in Olympic bouldering typically engage in slow thinking to interpret movements and explore climbing strategies. However, time constraints imposed by regulations, combined with ineffective decision-making and failed climbing attempts, may compel them to make more intuitive, fast decisions.
View Article and Find Full Text PDFDiscovery of Novel Na1.7-Selective Inhibitors with the 1-Indole-3-Propionamide Scaffold for Effective Pain Relief.
Research (Wash D C)
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Na1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy.
View Article and Find Full Text PDFPerioperative outcomes of robotic vs laparoscopic pancreatoduodenectomy: a meta-analysis and trial sequential analysis.
Surg Endosc
January 2025
Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, México.
Background: Minimally invasive pancreatoduodenectomy has gained widespread acceptance among hepatopancreatobiliary surgeons due to its demonstrated advantages in perioperative outcomes compared to the conventional open approach. This meta-analysis, along with trial sequential analysis, aimed to compare the outcomes of robotic pancreatoduodenectomy and laparoscopic pancreatoduodenectomy based on the current available evidence.
Methods: A systematic search of PubMed, Cochrane, Scopus, and Web of Science was conducted from inception to July 2024.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!