Comments on Meta-Analyses in General and in Stem Cell Research: An Overview and Cautionary Advice.

Stem Cells Dev

Carman and Ann Adam Department of Pediatrics, Children's Research Center of Michigan, Wayne State University School of Medicine, Detroit, Michigan.

Published: September 2015

AI Article Synopsis

  • Meta-analysis is a method used to combine findings from various studies and has been utilized for over 40 years.
  • Journal editors favor publishing meta-analyses as they blend research evidence with clinical expertise and patient preferences.
  • Though widely popular, there are common issues in meta-analysis procedures that researchers should understand to effectively assess and critique their findings.

Article Abstract

Meta-analysis, a tool for contrasting and combining results from different research studies, has been around now for over 40 years. Journal editors are eager to publish the results from meta-analyses, as they propose to represent the integration of best research evidence with clinical expertise and patient values. There are guidelines available, most notably through the Cochrane Collaborative, for investigators to follow in conducting a responsible and, therefore publishable, meta-analysis. Despite the burgeoning popularity of this powerful analytical tool, the procedure is not without its pitfalls. In this study, we advise the readership to familiarize themselves with the most common shortcomings in an effort to help elevate our ability to critically appraise the results of these analyses.

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Source
http://dx.doi.org/10.1089/scd.2015.29000.parDOI Listing

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