AI Article Synopsis
- Post-translational modifications (PTMs) like phosphorylation and acetylation significantly regulate transcription factors, which are vital for maintaining metabolic balance.
- Recent research highlights the specific impact of lysine acetylation on nonhistone proteins, including how it influences their activity, stability, and behavior within cells.
- This review discusses new findings about lysine acetylation in the context of transcriptional regulation, furthering our understanding of its role in metabolic homeostasis.
Article Abstract
Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624674 | PMC |
| http://dx.doi.org/10.1007/s13238-015-0204-y | DOI Listing |
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