AI Article Synopsis
- Epigenetic modifications, such as DNA methylation and histone changes, play a key role in the development of human cancer by interacting with genetic defects.
- These modifications are dynamic and reversible, making them potential targets for cancer biomarkers and therapies.
- Recent research suggests that dietary phytochemicals may help prevent cancer by influencing these epigenetic mechanisms, and the review will discuss advancements in this area from the last three years.
Article Abstract
Studies during the last two decades have revealed the involvement of epigenetic modifications in the development of human cancer. It is now recognized that the interplay of DNA methylation, post-translational histone modification, and non-coding RNAs can interact with genetic defects to drive tumorigenesis. The early onset, reversibility, and dynamic nature of such epigenetic modifications enable them to be developed as promising cancer biomarkers and preventive/therapeutic targets. In addition to the recent approval of several epigenetic therapies in the treatment of human cancer, emerging studies have indicated that dietary phytochemicals might exert cancer chemopreventive effects by targeting epigenetic mechanisms. In this review, we will present the current understanding of the epigenetic alterations in carcinogenesis and highlight the potential of targeting these mechanisms to treat/prevent cancer. The latest findings, published in the past three years regarding the effects of dietary phytochemicals in modulating epigenetic mechanisms will also be discussed.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552355 | PMC |
| http://dx.doi.org/10.1007/s40495-015-0023-0 | DOI Listing |
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