Objectives: To assess risk factors for caries development on approximal surfaces in contact with newly placed Class II composite restorations.
Methods: 750 surfaces, either sound or with caries confined to enamel, in contact with newly placed Class II composite restorations, placed by PDS dentists in Norway were evaluated by clinicians, using standardized clinical and radiographic criteria.
Results: After the observation period (mean 4.9 year, SD 0.67), 38.8% of the initially sound contact surfaces (n=417) remained sound, 34.0% developed caries confined to enamel and 27.2% developed caries into dentine. Of surfaces with caries confined to enamel present at baseline (n=333), 57.3% remained in enamel, while 42.7% progressed into dentine. Risk factors for dentine caries development were assessed by logistic regression analyses. The risk of developing caries on surfaces that were initially sound at baseline was higher in patients with poor or medium oral hygiene (OR 1.53; CI 1.10-3.68), higher DMFT at baseline (OR 1.12; Cl 1.04-1.20). Maxillary teeth (OR 2.01; Cl 1.14-3.56) and surfaces on the right side of the mouth (OR 1.65; Cl 1.01-2.72) were also risk factors. For surfaces with enamel caries present at baseline, the risk of dentine caries was higher in patients with higher DMFT (OR 1.06; CI 1.00-1.13). In both analyses the treating dentists had a significant impact on the caries development.
Conclusions: Both patient- and dentist related variables are risk factors for caries development on approximal surfaces in contact with newly placed Class II composite restorations.
Clinical Significance: All clinicians should be aware of a notable risk of caries development on the adjacent tooth surface, especially when placing approximal restorations in high caries risk patients, and should consider greater use of preventive strategies or non-operative treatment that should be evaluated and repeated at every recall.
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http://dx.doi.org/10.1016/j.jdent.2015.08.013 | DOI Listing |
JMIR Med Inform
January 2025
Department of Systems Design Engineering, Faculty of Engineering, University of Waterloo, Waterloo, ON, Canada.
Background: While expert optometrists tend to rely on a deep understanding of the disease and intuitive pattern recognition, those with less experience may depend more on extensive data, comparisons, and external guidance. Understanding these variations is important for developing artificial intelligence (AI) systems that can effectively support optometrists with varying degrees of experience and minimize decision inconsistencies.
Objective: The main objective of this study is to identify and analyze the variations in diagnostic decision-making approaches between novice and expert optometrists.
AIDS Care
January 2025
Department of Knowledge Management, Sociedad Integral de Especialistas en Salud (SIES Salud IPS), Bogotá, Colombia.
The most significant progress in addressing the HIV/AIDS epidemic has been the development of antiretroviral therapy (ART). However, ensuring a high degree of treatment adherence is necessary to prevent resistance and disease progression. We conducted a cross-sectional study to evaluate adherence to ART through the calculation of the medication possession ratio (MPR) and to identify risk factors for suboptimal adherence in a cohort of HIV-positive patients receiving care at a Colombian healthcare institution across 16 cities.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
Importance: Sensitivity to environmental stress and adversity may influence lung cancer risk, highlighting a critical link between psychosocial factors and cancer etiology.
Objective: To evaluate whether genetically estimated sensitivity to environmental stress and adversity is associated with lung cancer risk.
Design, Setting, And Participants: Data were obtained from a genome-wide association study identifying 37 independent genetic variants strongly associated with sensitivity to environmental stress and adversity and a cross-ancestry genome-wide meta-analysis from the International Lung Cancer Consortium.
J Vis Exp
January 2025
Institute of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China; National Health Commission Key Laboratory of Birth Defect Research and Preventio, Hunan Provincial Maternal and Child Health Care Hospital;
Both DNA replication and RNA transcription utilize genomic DNA as their template, necessitating spatial and temporal separation of these processes. Conflicts between the replication and transcription machinery, termed transcription-replication conflicts (TRCs), pose a considerable risk to genome stability, a critical factor in cancer development. While several factors regulating these collisions have been identified, pinpointing primary causes remains difficult due to limited tools for direct visualization and clear interpretation.
View Article and Find Full Text PDFAging Clin Exp Res
January 2025
Department of Physical Medicine and Rehabilitation, Kansai Medical University, Osaka, Japan.
Background: Falls on stairs are a major cause of severe injuries among older adults, with stair descent posing significantly greater risks than ascent. Variations in stair descent phenotypes may reflect differences in physical function and biomechanical stability, and their identification may prevent falls.
Aims: This study aims to classify stair descent phenotypes in older adults and investigate the biomechanical and physical functional differences between these phenotypes using hierarchical cluster analysis.
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