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Feasibility of the modified mini-bronchoalveolar lavage techniques using a nasogastric suction catheter and polytetrafluoroethylene bronchoscopic suction catheter in diagnosing bilateral pneumonia: a pilot study.
J Thorac Dis
May 2024
Division of Pulmonology and Respiratory Critical Care, Department of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Background: The adequacy of actual lower respiratory tract samples collected using the current collection technique is debated. Endotracheal aspiration is commonly insufficient and can be contaminated with colonization from the proximal airway. Diagnostic bronchoscopy is the standard method for collecting specimens from the lower respiratory tract.
View Article and Find Full Text PDFA Tale of Two Hospitals: Comparing CAPA Infections in Two ICUs During the Spanish Fourth Pandemic Wave.
Mycopathologia
August 2023
Microbiology and Parasitology Department, Hospital Universitario La Paz, Madrid, Spain.
Purpose: COVID-19 associated pulmonary aspergillosis (CAPA) is a new clinical entity linked to SARS-CoV-2 infection that is causing a rise on the risk of complications and mortality, particularly in critical patients.
Methods: We compared diagnostic and clinical features in two cohorts of patients with severe COVID-19 admitted in the intensive care units (ICU) of two different hospitals in Madrid, Spain, between February and June 2021. Clinical and microbiological relevant aspects for CAPA diagnosis were collected for further classification.
Aerosolized Antibiotics to Manage Ventilator-Associated Infections: A Comprehensive Review.
Antibiotics (Basel)
April 2023
Department of Intensive Care Medicine, University Hospital of Larissa, 41110 Larissa, Greece.
Background: Ventilator-associated lower respiratory tract infectious complications in critically ill patients cover a wide spectrum of one disease process (respiratory infection), initiating from tracheal tube and/or tracheobronchial colonization, to ventilator associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). VAP occurence has been associated with increased intensive care unit (ICU) morbidity (ventilator days, as well as length of ICU and hospital stay) and ICU mortality. Therefore, treatments that aim at VAP/VAT incidence reduction are a high priority.
View Article and Find Full Text PDFDelivery Mode Shapes the Composition of the Lower Airways Microbiota in Newborns.
Front Cell Infect Microbiol
January 2022
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Radical alterations in the human microbiota composition are well-known to be associated with many pathological conditions. If these aberrations are established at the time of birth, the risk of developing correlated pathologies throughout life is significantly increased. For this reason, all newborns should begin their lives with a proper microbiota in each body district.
View Article and Find Full Text PDFFungal infections in lung transplantation.
J Thorac Dis
November 2021
University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Lung transplant is a potential life-saving procedure for chronic lung diseases. Lung transplant recipients (LTRs) are at the greatest risk for invasive fungal infections (IFIs) among solid organ transplant (SOT) recipients because the allograft is directly exposed to fungi in the environment, airway and lung host defenses are impaired, and immunosuppressive regimens are particularly intense. IFIs occur within a year of transplant in 3-19% of LTRs, and they are associated with high mortality, prolonged hospital stays, and excess healthcare costs.
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