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Oral pre- and early postnatal cannabis exposure disinhibits ventral tegmental area dopamine neuron activity but does not influence cocaine preference in offspring in mice.
J Neurosci Res
July 2024
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- Cannabis use in Canada rose from 1.5% to 2.5% between 2012 and 2019, prompting studies on prenatal cannabis exposure and its potential impacts on birth weight and neurodevelopment, complicated by various factors.
- Research utilizing animal models, specifically a study with mice, controls for dose and timing by exposing mothers to THC through a peanut butter diet during pregnancy and early postnatal life.
- Findings revealed that male offspring had altered VTA dopamine neuron activity but exhibited no changes in cocaine-seeking behavior, indicating that prenatal cannabis exposure can impact neurodevelopment in a sex-specific manner.
Cannabis-Induced Anxiety Disorder in the Emergency Department.
Cureus
April 2023
Emergency Medicine, Spectrum Health Medical Group, Grand Rapids, USA.
Background: In December 2018, Michigan became the 10th state to legalize marijuana for adults. Since this law took effect, increased availability and use of cannabis in Michigan have led to increased emergency department (ED) visits associated with the drug's psychiatric effects.
Objectives: To describe cannabis-induced anxiety disorder's prevalence, clinical features, and disposition in a community-based study.
Cannabis-Induced Acute Encephalopathy in a 94-Year-Old Woman Due to Family Administration of Cannabidiol (CBD) Products: A Case Report.
Cureus
April 2023
Division of Hospital Medicine, Emory University School of Medicine, Atlanta, USA.
In the United States, cannabis use is rising, including among older adults, as is unintentional ingestion. We describe the case of a 94-year-old woman admitted with altered mental status, diarrhea, and hallucinations. She lived with her family, who had noticed recent confusion with weakness, poor oral intake, and loose bowel movements.
View Article and Find Full Text PDFPrevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America.
PLoS One
April 2022
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Cannabis legalization in North America has coincided with an increase in reports of cannabis-induced toxicosis in pets, but the magnitude of this problem, as well as outcomes of these incidents remain unknown. Therefore, we examined the frequency, diagnostic criteria, clinical signs, and prognoses of cannabis toxicoses in pets in North America. We conducted an online survey between January, 2021 and April, 2021 targeting veterinarians practicing in Canada and the United States (US).
View Article and Find Full Text PDFAssessment of cognitive and psychomotor impairment, subjective effects, and blood THC concentrations following acute administration of oral and vaporized cannabis.
J Psychopharmacol
July 2021
Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Cannabis legalization is expanding, but there are no established methods for detecting cannabis impairment.
Aim: Characterize the acute impairing effects of oral and vaporized cannabis using various performance tests.
Methods: Participants ( = 20, 10 men/10 women) who were infrequent cannabis users ingested cannabis brownies (0, 10, and 25 mg Δ-9-tetrahydrocannabinol, THC) and inhaled vaporized cannabis (0, 5, and 20 mg THC) in six double-blind outpatient sessions.
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