AI Article Synopsis
- The study investigates the use of porous starch (PS) as a carrier for total Epimedium flavonoids (TEF), using the dissolution of icariin as a measurement tool.
- Analysis methods like scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRD) were employed to characterize TEF and its solid dispersions, revealing that TEF likely exists in an amorphous state within the solid dispersion.
- The results showed a significant increase in the dissolution rate of icariin when TEF and PS were combined in a 1:2 ratio, indicating that PS as a solid dispersion carrier merits further exploration.
Article Abstract
In order to evaluate the characteristic of porous starch (PS) as the solid dispersions carrier of the total Epimedium flavonoids (TEF), the PS was used. The dissolution of icariin was selected as an indicator to analyze the differences of dissolution between TEF and its solid dispersion. TEF was characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD). Solid dispersion was irregular block and no powder characteristics of TEF and PS could be seen in SEM, DSC and XRD analysis suggested that TEF may be present in solid dispersion as amorphous substance. The dissolution rate of icariin has been improved significantly when the proportion of TEF and PS was 1:2. PS as a traditional solid dispersion carrier is worthy of further study.
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