AI Article Synopsis
- Vision loss from retinal degeneration is a major global health issue, impacting millions.
- In a study, human bone marrow stem cells were transplanted in RCS rats, showing positive results by protecting retinal function for up to 20 weeks.
- The procedure involved minimal side effects, indicating that this method of cell transplantation may be a promising treatment for retinal degeneration.
Article Abstract
Vision incapacitation and blindness associated with incurable retinal degeneration affect millions of people worldwide. In this study, 0.25×10(6) human bone marrow stem cells (hBM-MSCs) were transplanted epiretinally in the right eye of Royal College Surgeons (RCS) rats at the age of 28 days. Epiretinally transplanted cells were identified as a thin layer of cells along vitreous cavity, in close proximity to the retina or attached to the lens capsule, up to 6 weeks following transplantation. Epiretinal transplantation delayed photoreceptor degeneration and rescued retinal function up to 20 weeks following cell transplantation. Visual functions remained close to normal levels in epiretinal transplantation rats. No inflammation or any other adverse effects were observed in transplanted eyes. Our findings suggest that transplantation of hBM-MSCs as a thin epiretinal layer is effective for treatment of retinal degeneration in RCS rats, and that transplanting the cells in close proximity to the retina enhances hBM-MSC therapeutic effect compared with intravitreal injection.
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| http://dx.doi.org/10.1016/j.scr.2015.08.007 | DOI Listing |
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