AI Article Synopsis
- The study explored how tuberculosis clinical features impact the infectiousness of HIV-positive miners in South Africa using data from 1589 participants.
- Sputum smear-positivity (SS+) was highest (55.3%) in individuals with low CD4 counts (<100 cells/μL), indicating that low immune function increases infectiousness.
- Findings revealed that while combination antiretroviral therapy (cART) did not independently influence SS+ or pulmonary cavitation, it may enhance infectiousness by improving CD4 cell recovery.
Article Abstract
Clinical features of tuberculosis influence infectiousness. This cross-sectional study examined the effect of combination antiretroviral therapy (cART) and CD4 on sputum smear-positivity (SS+) and pulmonary cavitation among 1589 (1185/1589 HIV-positive) miners in South Africa. Proportions SS+ varied nonlinearly by CD4 with greatest proportions SS+ (55.3%) in the lowest stratum (<100 cells/μL). Adjusted prevalence ratio for SS+; on vs. off cART was 0.90 (95% confidence interval: 0.73 to 1.11). Proportions with cavitation varied linearly with CD4, with no independent cART effect (adjusted prevalence ratio 1.17; 95% confidence interval: 0.80 to 1.71). cART did not independently affect SS+ or cavitation but may increase infectiousness through CD4 recovery.
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| http://dx.doi.org/10.1097/QAI.0000000000000684 | DOI Listing |
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