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Ocular infections in international travelers.
Travel Med Infect Dis
November 2024
National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, CIBERINFEC, Madrid, Spain.
Introduction: Ophthalmological conditions in international travelers may be associated with low mortality but high morbidity. Eye involvement in travelers is less frequently reported than febrile, gastrointestinal and respiratory infections, but data probably represent a degree of under-notification.
Methods: an extensive narrative review of the main viral, bacterial, fungal and parasitic infections affecting the eye in travelers was performed.
[Ocular toxoplasmosis].
J Fr Ophtalmol
December 2024
Service d'ophtalmologie, Croix Rousse Hospital, hospices civils de Lyon 1, université de Lyon 1, Lyon, France.
Article Synopsis
- Ocular toxoplasmosis, caused by the parasite Toxoplasma gondii, is the leading cause of posterior uveitis globally, affecting about 8.4% of people.
- Diagnosis primarily involves a clinical exam for signs of uveitis, particularly retinochoroiditis, with microbiological tests providing confirmation.
- There is ongoing debate regarding the necessity and approach to treatment for both acute cases and recurrent infections.
Enhanced clindamycin delivery using chitosan-coated niosomes to prevent Toxoplasma gondii strain VEG in pregnant mice: an experimental study.
Trop Med Health
September 2024
Laboratory of Molecular Parasitology, Scientific Center of Zoology and Hydroecology, NASRA, 7P. Sevak St., 0014, Yerevan, Armenia.
Article Synopsis
- Congenital toxoplasmosis in pregnant women is primarily caused by the first-time infection of Toxoplasma gondii, and treatments typically involve antibiotics like spiramycin and clindamycin, each with limitations in efficacy due to poor placental penetration.
- A study investigated the use of chitosan-coated niosomes (Cs-Nio) to enhance the delivery and effectiveness of clindamycin against the VEG strain of T. gondii in a pregnant mouse model.
- Results showed that Cs-Nio-Cli treatment significantly reduced T. gondii cysts in the brain and eyes, improved tissue health, and reduced inflammation and cell death, demonstrating a promising approach to treat congenital toxoplasmosis.
Human Ocular Toxoplasmosis in Romania: History, Epidemiology, and Public Health: A Narrative Review.
Microorganisms
July 2024
Discipline of Parasitology, Department of Infectious Disease, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Article Synopsis
- * The review summarizes research on ocular toxoplasmosis, which causes infectious posterior uveitis, highlighting its clinical presentation and diagnosis methods such as fundus photography and OCT.
- * The study emphasizes the necessity for better diagnostic techniques, more research, and public health education to address the impact of toxoplasmosis in Romania.
Indocyanine green angiography reveals choroidal hypoperfusion in subacute sclerosing panencephalitis (SSPE).
Eur J Ophthalmol
November 2024
Uvea Services, Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India.
We report the choroidal findings on indocyanine green angiography (ICGA) in two cases of subacute sclerosing panencephalitis (SSPE). The two immunocompetent patients (31-year-old and 30-year-old Asian Indian males) presented with acute-onset rapidly progressing vision loss with findings of necrotizing retinitis involving the central macula. Both patients tested negative for serological evidence of herpes or varicella, and toxoplasma antibodies.
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