Background: The aim of the present study was to evaluate a non-destructive fabrication method in for the development of sustained-release poly (L, D-lactic acid)-based biodegradable clindamycin phosphate implants for the treatment of ocular toxoplasmosis.
Materials And Methods: The rod-shaped intravitreal implants with an average length of 5 mm and a diameter of 0.4 mm were evaluated for their physicochemical parameters. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR), and nuclear magnetic resonance (1H NMR) studies were employed in order to study the characteristics of these formulations.
Results: Drug content uniformity test confirmed the uniformity in different implant batches. Furthermore, the DSC, FTIR, and 1H NMR studies proved that the fabrication process did not have any destructive effects either on the drug or on the polymer structures.
Conclusion: These studies showed that the developed sustained-release implants could be of interest for long-term sustained intraocular delivery of clindamycin, which can provide better patient compliance and also have good potential in terms of industrial feasibility.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549919 | PMC |
| http://dx.doi.org/10.4103/2277-9175.161563 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The influence of UV-visible light, microwave radiation, argon laser, and heating and aging processes on silicone oil utilized as intravitreal implants: Experimental exposure with clinical correlation.
PLoS One
December 2024
Division of Ophthalmology, Department of Special Surgery, Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan.
Purpose: The emulsification of silicone oil (SO) remains poorly understood. In the present study, we investigated the physical properties of unused pharmaceutical SO samples under various conditions. Moreover, clinical correlations with the patients' SO samples were assessed.
View Article and Find Full Text PDFInjectable Intravitreal Fluocinolone Acetonide Implant for Chronic Postoperative CME in the Presence of Silicone Oil Tamponade.
Retin Cases Brief Rep
October 2024
Texas Retina Associates, Dallas, Texas.
Purpose: This report describes the use of the injectable intravitreal fluocinolone acetonide 0.18mg implant (FAI) for chronic postoperative cystoid macular edema (CME) in an eye with a silicone oil-filled vitreous cavity.
Methods: A retrospective chart review was performed including surgical, clinical, and imaging data.
An Unusual Case of Exudative Retinal Detachment in a 6-Year-Old Child with Acute Retinal Necrosis.
Ocul Immunol Inflamm
December 2024
Uvea Services, Sankara Nethralaya, Chennai, India.
Purpose: To report a case of exudative retinal detachment (ERD) in a child with Acute retinal necrosis (ARN).
Method: Retrospective Chart Review.
Result: A six-year-old boy presented with anterior uveitis with hypopyon and exudative retinal detachment with peripheral confluent patches of retinitis in the left eye.
Development of axitinib-loaded polymeric ocular implants for the treatment of posterior ocular diseases.
Int J Pharm
December 2024
School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom. Electronic address:
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the primary causes of vision impairment and blindness worldwide. The current treatment for these diseases is an intravitreal injection of anti-VEGF agents, which are costly and require frequent injections. Implants can be used to sustain the release of drugs and minimize side effects.
View Article and Find Full Text PDFSimultaneous placement of a bone cement implant after evisceration surgery in patients diagnosed with infectious endophthalmitis.
Arch Soc Esp Oftalmol (Engl Ed)
December 2024
Departamento de Oculoplástica, Instituto de Oftalmología Fundación Conde de Valenciana, Mexico City, Mexico. Electronic address:
Background And Objectives: Endophthalmitis is a type of eye inflammation that affects all structures of the eye and is generally of infectious origin. In cases recalcitrant to intravitreal treatment or posterior vitrectomy, evisceration or enucleation are the preferable options. Polymethylmethacrylate (PMMA) bone cement has stood out as an implant in other areas of medicine due to its great stability and healing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!