Pyoderma gangrenosum (PG) is an orphan disease. It belongs to the group of neutrophilic dermatoses. Four major subtypes and several rare manifestations illustrate the great variety of clinical presentations and clinical course. PG is potentially life threatening and associated with a number of internal diseases including chronic inflammatory bowel disease, hematologic disorders, and malignancies. PG itself shows extracutaneous manifestations. These findings are in favor of PG as a systemic disease.
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Assessing the role of wound debridement in pyoderma gangrenosum-A retrospective cohort study.
Wound Repair Regen
November 2024
Department of Internal Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- The study examined the effects of wound debridement on patients with pyoderma gangrenosum (PG), highlighting the concern of pathergy (worsening of wounds due to intervention).
- Among 104 patients analyzed, those undergoing debridement showed significantly lower remission rates (60.53%) compared to those treated with immunosuppression alone (87.88%), along with a longer average time to remission (12.3 months vs. 8.67 months).
- The results indicated higher rates of disease progression and the need for additional procedures in the debridement group, suggesting that debridement may worsen healing outcomes in PG and should be avoided in treatment.
Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum-A systematic review.
Wound Repair Regen
March 2021
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Chronic painful ulcers caused by pyoderma gangrenosum (PG) and cutaneous vasculitis remain to be a therapeutic challenge. Skin grafts have been used with success in selected cases but are generally avoided due to the fear of pathergy. The aim of this study was to investigate the safety and efficacy of skin grafting in the treatment of primary vasculitic ulcer (PVU) and PG.
View Article and Find Full Text PDFEditorial: peristomal pyoderma gangrenosum-a challenge for patients, healthcare professionals and research.
Aliment Pharmacol Ther
July 2020
Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Risk of developing pyoderma gangrenosum after procedures in patients with a known history of pyoderma gangrenosum-A retrospective analysis.
J Am Acad Dermatol
February 2018
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
Background: The risk of postoperative pyoderma gangrenosum (PG) in patients with a known history of PG is unknown.
Objective: To quantify risk and identify patient- and/or procedure-related risk factors for postsurgical recurrence or exacerbation of PG in patients with a known history of PG.
Methods: We retrospectively evaluated the likelihood of postsurgical recurrence or exacerbation of PG for all patients with a confirmed diagnosis of PG at Brigham and Women's Hospital and Massachusetts General Hospital from 2000 to 2015.
Pyoderma gangrenosum-a novel approach?
Wien Med Wochenschr
March 2017
Onkoderma - Policlinic for Dermatology and Dermatologic surgery, 26 General Scobelev, Sofia, Bulgaria.
Pyoderma gangrenosum (PG) represents a rare skin disorder, with several clinical variants and still not fully understood ethiopathogenesis. Often associated with inflammatory or neoplastic disease, PG is nowadays considered an inflammatory neutrophilic disease with common underlying morbidity. Modern treatment options are oriented towards key mechanisms underlying the pathogenesis of the disease, namely inflammatory mediators, and seem to be the most effective treatment currently available.
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