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| http://dx.doi.org/10.1212/WNL.0000000000001973 | DOI Listing |
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Intracerebral hemorrhage in CADASIL.
J Chin Med Assoc
January 2025
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene. This review highlights the increasing recognition of intracerebral hemorrhage (ICH) as a significant manifestation of CADASIL, often predominantly characterized by ischemic strokes and vascular dementia. Recent studies indicate that the prevalence of ICH in CADASIL patients ranges from 0.
View Article and Find Full Text PDFFreeze-dried plasma: Hemostasis and biophysical analyses for damage control resuscitation.
Transfusion
January 2025
Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Background: Effective hemorrhage protocols prioritize immediate hemostatic resuscitation to manage hemorrhagic shock. Prehospital resuscitation using blood products, such as whole blood or alternatively dried plasma in its absence, has the potential to improve outcomes in hemorrhagic shock patients. However, integrating blood products into prehospital care poses substantial logistical challenges due to issues with storage, transport, and administration in field environments.
View Article and Find Full Text PDFUtilizing Quantitative Analysis of CSF Volume from Clinical T1-Weighted MRI to Predict Thrombectomy Outcomes.
J Neuroimaging
January 2025
Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Background And Purpose: Endovascular thrombectomy (EVT) is the standard for acute ischemic stroke from large vessel occlusion, but post-EVT functional independence varies. Brain atrophy, linked to higher cerebrospinal fluid volume (CSFV), may affect outcomes. Baseline CSFV could predict EVT benefit by assessing brain health.
View Article and Find Full Text PDFMechanical Thrombectomy for Acute Ischemic Stroke in Nonagenarians: A Dilemma in Treatment Approach.
Cureus
December 2024
Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND.
Stroke is one of the major causes of mortality and morbidity, particularly among the elderly population. As the general population ages, cerebrovascular disease is anticipated to increase in prevalence. Strokes can manifest as either hemorrhagic or ischemic events.
View Article and Find Full Text PDFSystolic Blood Pressure Time in Target Range and Cardiovascular Disease and Premature Death.
JACC Asia
December 2024
Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Background: Previous research has suggested that time-in-target range (TTR) for systolic blood pressure (SBP) was associated with adverse cardiovascular events, but real-world data studies remain limited.
Objectives: The purpose of this study was to estimate the SBP-TTR associated with cardiovascular disease (CVD) and premature death among the employed individuals with hypertension.
Methods: This study included 9,552 participants from the workplace hypertension management program initiated by the Kailuan Study in 2009.
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