As group A Streptococcus (GAS) meningitis is seldom reported in children, emm-type distribution data are scare. We report eight cases of GAS meningitis in Belgium (2008-2013) and compare molecular characteristics of our strains with a further 55 cases previously reported with their corresponding emm-types. emm1 type was the most frequent (24%) followed by emm6 (11%), emm12 (11%) and emm3 (6%). Together these four emm-types accounted for 52% of the cases, while the rest of the cases are due to 24 different emm-types. These 28 emm-types associated with GAS meningitis belonged to 16 different emm-clusters suggesting that there is no propensity for particular emm-types or emm-cluster to cause meningitis. Theoretical coverage of the 30-valent vaccine candidate would be 77.8% (49/63 isolates) among children with GAS meningitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1179/2295333715Y.0000000066 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Invasive infections by group A Streptococcus infections in Brazil: a pediatric case series.
Rev Paul Pediatr
January 2025
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Objective: Group A Streptococcus (GAS) are Gram-positive cocci that colonize the nasopharynx and/or skin and in rare cases may cause severe invasive infections. Although these infections decreased during the COVID-19 pandemic, some countries have observed an increased number of invasive GAS (iGAS) diseases in recent years. The objective of this study was to describe a series of iGAS diseases in a referral hospital for the treatment of pediatric infectious disease in Minas Gerais State, Brazil, between September 2022 and August 2023.
View Article and Find Full Text PDFValidation of glucose and lactate in cerebrospinal fluid (CSF) on a Radiometer blood gas analyzer ABL90 Flex plus.
Clin Biochem
January 2025
Pathology and Laboratory Medicine Program, Health Sciences Centre, St. John's, Newfoundland and Labrador, Canada; Memorial University of Newfoundland, Health Sciences Centre, St. John's, Newfoundland and Labrador, Canada. Electronic address:
Purpose: Rapid determination of cerebrospinal fluid (CSF) glucose and lactate is required by emergency rooms and intensive care units. Long turnaround time (TAT) on test results negatively impacts timely diagnosis and treatment of neurological infections like meningitis.
Methods: The CSF glucose and lactate assays were evaluated on a blood gas analyzer, Radiometer ABL90 Flex Plus.
Invasive group A streptococcal infections as a consequence of coexisting or previous viral infection in the post-COVID-19 pandemic period.
J Infect Public Health
January 2025
Department of Infectious Diseases and Child Neurology, Institute of Paediatrics, Poznan University of Medical Sciences, Poland.
Background: Group A Streptococci (GAS) may cause infections of the pharynx and soft tissues and invasive infections in children (iGAS). A significant increase in severe iGAS infections has been reported in Europe since the fall of 2022.
Objectives: This retrospective study aims to analyse clinical data of children with invasive and non-invasive GAS infections in the post-COVID-19 pandemic era, searching for predisposing factors to developing invasive infections.
Targeted metabolomics investigation of metabolic markers of Mycobacterium tuberculosis in the cerebrospinal fluid of paediatric patients with tuberculous meningitis.
PLoS One
December 2024
Biochemistry Department, Focus Area for Human Metabolomics, North-West University, Potchefstroom, South Africa.
Article Synopsis
- - This study aimed to explore metabolic markers associated with Mycobacterium tuberculosis (M. tb) in the cerebrospinal fluid (CSF) of South African children suffering from tuberculous meningitis (TBM) using advanced metabolomics techniques.
- - Four key metabolites were found to distinguish TBM patients from controls: lower levels of mannose and arabinose, and higher levels of nonanoic acid and propanoic acid in the TBM group.
- - The research suggests that nonanoic acid may be a novel M. tb-linked marker in TBM, while propanoic acid could indicate brain energy disruptions and inflammation; however, mannose and arabinose were not effective markers for M.
Association Between Neuropsychiatric Event and Systemic Lupus Erythematosus Clinical Manifestation: A Meta-Analysis.
J Coll Physicians Surg Pak
December 2024
Department of Rheumatology and Nephrology, Huabei Petroleum Administration Bureau General Hospital, Renqiu, China.
To uncover the clinical characteristics and investigate the underlying causes of psychiatric manifestations in patients with systemic lupus erythematosus (SLE), including its subset, neuropsychiatric systemic lupus erythematosus (NPSLE). Through comprehensive database searches in PubMed, Embase, Medline, and Cochrane, from their inception to August 2023, the study focused on adult SLE and NPSLE cases. From the selected studies, data were synthesised via a random-effects meta-analysis, encompassing a total of 2,997 subjects across six studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!