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Examination of Gallbladders at Military Treatment Facilities: Is Histologic Analysis Necessary?
Mil Med
January 2025
Department of Pathology and Area Laboratory Services, Brooke Army Medical Center, San Antonio, TX 78234, USA.
Introduction: Gallbladder specimens from cholecystectomy procedures are a common specimen evaluated by military pathologists. These are often removed for inflammatory causes. Previous studies show that the incidence of gallbladder carcinoma (GBC) is around 3%.
View Article and Find Full Text PDFTargeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report.
World J Gastrointest Oncol
January 2025
Department of Medical College, Jinan University, Guangzhou 510000, Guangdong Province, China.
Background: Gallbladder neuroendocrine carcinoma (NEC) represents a subtype of gallbladder malignancies characterized by a low incidence, aggressive nature, and poor prognosis. Despite its clinical severity, the genetic alterations, mechanisms, and signaling pathways underlying gallbladder NEC remain unclear.
Case Summary: This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient, who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and V.
Incidental Visualization of Gallbladder on Post-therapy [ Lu]Lu-DOTATATE Scintigraphy Mimicking a Liver Metastasis in a Duodenal Neuroendocrine Tumor.
World J Nucl Med
December 2024
Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
We present a rare case of physiological uptake of [ Lu]Lu-DOTATATE in the gallbladder, observed post-therapy, in a 47-year-old man with grade I duodenal neuroendocrine tumor (NET), despite no uptake being observed pre-therapy in the somatostatin receptor-positron emission tomography. On planar scintigraphy, the gallbladder uptake could have been misidentified as liver metastasis. By utilizing single photon emission computed tomography/computed tomography imaging, we were able to precisely localize the tracer and obtain anatomical morphological characteristics, thereby averting the potential for misinterpretation of liver metastasis resulting from the gallbladder's physiological uptake of [ Lu]Lu-DOTATATE in NET patients.
View Article and Find Full Text PDFEndoscopic Ultrasound-Guided Diagnosis of Gallbladder Mixed Neuroendocrine Non-Neuroendocrine Tumor With an Anomalous Pancreaticobiliary Junction.
ACG Case Rep J
December 2024
Department of Gastroenterology, Tufts Medical Center, Boston, MA.
Mixed neuroendocrine non-neuroendocrine neoplasms are exceedingly rare tumors, especially those of gallbladder origin. Anomalous pancreaticobiliary junction is an uncommon congenital abnormality that can predispose various types of hepatobiliary malignancies. We present an unusual case of a 46-year-old woman with anomalous pancreaticobiliary junction who presented to the emergency department with nausea, vomiting, and right upper quadrant pain.
View Article and Find Full Text PDFPrimary gallbladder neuroendocrine neoplasm: A case report of grade 1 well-differentiated neuroendocrine tumor.
Int J Surg Case Rep
December 2024
Department of Surgery, Royal Columbian Hospital, Fraser Health Authority, 330 East Columbia Street, New Westminster, British Columbia V3L 3W7, Canada; University of British Columbia, Faculty of Medicine, Department of Surgery, 2775 Laurel Street, 11th Floor, Vancouver, British Columbia V5Z 1M9, Canada. Electronic address:
Introduction: Neuroendocrine neoplasm (NENs) make up approximately 2-3 % of gallbladder malignancies, while only 0.5 % of all NENs develop in the gallbladder. Most Gallbladder neuroendocrine neoplasms (GB-NENs) are discovered incidentally during pathological examinations post-cholecystectomy.
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