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Retinoic acid-loaded liposomes induce human mucosal CD103 dendritic cells that inhibit Th17 cells and drive regulatory T-cell development in vitro.
Eur J Immunol
May 2024
Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, The Netherlands.
The active vitamin A metabolite, all-trans-retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103. CD103 DCs can counteract pathogenic Th1 and Th17 in inflammatory bowel disease (IBD) or celiac disease (CD). Tolerogenic manipulation of DCs using nanoparticles carrying tolerogenic adjuvants and disease-specific antigens is a valuable treatment strategy to induce antigen-specific mucosal tolerance in vivo.
View Article and Find Full Text PDFIntestinal Tr1 Cells Confer Protection against Colitis in the Absence of Foxp3+ Regulatory T Cell-Derived IL-10.
Immunohorizons
June 2023
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH.
The intestinal mucosa is continually exposed to diverse microbial and dietary Ags, requiring coordinated efforts by specialized populations of regulatory T cells (Tregs) to maintain homeostasis. Suppressive mechanisms used by intestinal Tregs include the secretion of anti-inflammatory cytokines such as IL-10 and TGF-β. Defects in IL-10 signaling are associated with severe infantile enterocolitis in humans, and mice deficient in IL-10 or its receptors develop spontaneous colitis.
View Article and Find Full Text PDFMagnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome.
EBioMedicine
June 2023
Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States. Electronic address:
Background: Rheumatoid arthritis (RA) is a common autoimmune disease with emerging environmental and microbiome risk factors. The western diet is typically deficient in magnesium (Mg), and there is some evidence suggesting that Mg may have anti-inflammatory properties. But the actual role of Mg supplementation in arthritis or in T cell subsets has not been explored.
View Article and Find Full Text PDFSuppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice.
Cell Immunol
March 2023
Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
Article Synopsis
- - The study investigated the use of oral anti-CD3 monoclonal antibodies to prevent the formation of anti-drug antibodies (ADAs) in hemophilia A mice undergoing clotting factor VIII (FVIII) protein replacement therapy.
- - Administering low-dose oral anti-CD3 F(ab') led to a reduction in neutralizing ADAs, especially when given at the same time as FVIII therapy, with immune tolerance linked to certain populations of CD4 T cells.
- - Combining oral anti-CD3 treatment with oral FVIII antigen intake did not enhance the suppression of ADAs, indicating that while oral anti-CD3 shows promise, its mechanisms of action are different and not synergistic with the FVIII antigen approach.
Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease.
Front Immunol
January 2023
Paediatric Gastroenterology-Hepatology, Koç University Hospital, Istanbul, Türkiye.
Introduction: Autoimmune hepatitis (AIH) is a chronic liver disease caused by a perturbed immune system. The scarcity of short- and long-term immune monitoring of AIH hampered us to comprehend the interaction between immunosuppressive medication and immune homeostasis.
Methods And Patients: We recruited children with AIH at the time of diagnosis and at the 1st, 3rd, 6th, 12th, 18th, and 24th months of immunosuppression (IS).
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